PHARMACOLOGIC STUDY OF QINGHAO

Pharmacology Research Laboratory of the Institute of Chinese Materia Medica; Academy of Traditional Chinese Medicine

doi:10.13288/j.11-2166/r.1979.01.022

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PHARMACOLOGIC STUDY OF QINGHAO

更新时间：2021-11-20

- PHARMACOLOGIC STUDY OF QINGHAO
- Journal of Traditional Chinese Medicine Issue 1, Pages: 23-33(1979)
- 作者机构：
  
  中医研究院中药研究所药理研究室
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.1979.01.022
  CLC：
- Published：1979
- 稿件说明：
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[1].青蒿的药理研究[J].新医药学杂志,1979(01):23-33.

Pharmacology Research Laboratory of the Institute of Chinese Materia Medica, Academy of Traditional Chinese Medicine. PHARMACOLOGIC STUDY OF QINGHAO[J]. Journal of Traditional Chinese Medicine1979, (1): 23-33.
[1].青蒿的药理研究[J].新医药学杂志,1979(01):23-33. DOI： 10.13288/j.11-2166/r.1979.01.022.

Pharmacology Research Laboratory of the Institute of Chinese Materia Medica, Academy of Traditional Chinese Medicine. PHARMACOLOGIC STUDY OF QINGHAO[J]. Journal of Traditional Chinese Medicine1979, (1): 23-33. DOI： 10.13288/j.11-2166/r.1979.01.022.

摘要

本文内容包含有青蒿的抗疟作用及毒性试验、

H-青蒿素和

H-还原青蒿素体内过程的研究以及青蒿素对鼠疟原虫超微结构的影响等三个部分。动物实验证明

青蒿素主要作用于疟原虫红内期

而对疟原虫红前期及组织期均无效。青蒿素在体内吸收快

分布广

排泄快。动物实验及人体试服观察表明

青蒿提取的抗疟有效部分及其有效单体青蒿素对动物及人体主要脏器均无明显影响

说明其毒副作用是小的。通过电子显微镜观察

证明青蒿素系作用于疟原虫滋养体的膜系结构

干扰表膜-线粒体的功能

从而起到杀灭疟原虫的作用。

Abstract

Pharmacological experiments showed that Qinghaosu directly killed malaria parasites in erythrocytic stage

but not in tissue stage.Qinghaosu has a very low toxicity to experimental animals. It can be seen under the electromicroscope that Qinghaosu acts mainly at the mem- branous construction of plasmodium berghei.It unlike the chloroquine

interferes with the function of membrane-mitochondria. Qinghaosu can be distributed widely

absorbed and excreted quickly in vivo.

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