Study of the Antimalarial Mechanism and Synergic Action of "Qinghaosu" （A Sesquiterpene lactone from Artemisia annua L）

Zhao Yi

doi:10.13288/j.11-2166/r.1979.11.020

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Study of the Antimalarial Mechanism and Synergic Action of "Qinghaosu" （A Sesquiterpene lactone from Artemisia annua L）

更新时间：2021-11-22

- Study of the Antimalarial Mechanism and Synergic Action of "Qinghaosu" （A Sesquiterpene lactone from Artemisia annua L）
- Journal of Traditional Chinese Medicine Issue 11, Pages: 58-60(1979)
- 作者机构：
  
  广西中医学院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.1979.11.020
  CLC：
- Published：1979
- 稿件说明：
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[1]赵一,李爱媛,周芳.青蒿素抗疟作用原理与增效的探讨[J].中医杂志,1979(11):58-60.

Zhao Yi. Study of the Antimalarial Mechanism and Synergic Action of "Qinghaosu" （A Sesquiterpene lactone from Artemisia annua L）[J]. Journal of Traditional Chinese Medicine1979, (11): 58-60.
[1]赵一,李爱媛,周芳.青蒿素抗疟作用原理与增效的探讨[J].中医杂志,1979(11):58-60. DOI： 10.13288/j.11-2166/r.1979.11.020.

Zhao Yi. Study of the Antimalarial Mechanism and Synergic Action of "Qinghaosu" （A Sesquiterpene lactone from Artemisia annua L）[J]. Journal of Traditional Chinese Medicine1979, (11): 58-60. DOI： 10.13288/j.11-2166/r.1979.11.020.

摘要

<正> 青蒿素是我国医药卫生科技人员从祖国医药宝库里发掘出来的一种新型抗疟药。经过反复的动物实验和系统的临床观察

证明它在治疗疟疾方面具有高效、速效、低毒等优点

但还存在近期复发的缺点。克服此缺点的研究途径很多

例如青蒿素化学结构的改造、改进给药方法、合并用药等。我们考虑从青蒿素抗疟作用原理与增效的探讨入手

希望能降低其近期复发率

使其能更好地发挥抗疟效用。

Abstract

Unlike pyrimethamine

chloroquine or sulfonamides

the antimalarial mechauism of Qinghaosu doesn’t reveal competitive inhibition to the metabolism of folic acid

it might act through some other mechanism （such as the disturbance of the metabolism of nucleic acid and sugar） which needs further investigation.The antimalarial action was strengthened by the combined use of Qinghaosu and TMP. It prevents the recurrence of the disease. The author suggests that the drug should be identified through clinical application.

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