The antitumor effect of Spirobolus bun-gii extracts was studied in mice with soliduterocervical carcinoma(U

14

)

sarcoma

37

(S

37

)

Lewis lung carcinoma（Lewis）andascites uterocervical carcinoma(U

14

A)

sar-coma

180

(S

180

A)

Ehrlich tumor（ECA）.The agents tested included water

ethanol

ether and ethanol-ether extracts.All extractswere administered in solid tumor-bearingmice intraperitoneally for 12—14 days andascites tumor-bearing mice for 4—8 days.The optimal daily dose established for these4 extracts was 0.3

1.3

0.15—0.3 and 0.05—0.2 gm/kg respectively.The tumor growthinhibiting effect was determined for theseextracts in animal with U

14

Lewis and U

14

A

S

180

A

ECA;it ranged from 28.2 to 59.8%in solid tumor and from 72.8 to more than95% in ascites

but water extract showed noinhibiting effect on growth.Treating theanimal with U

14

by ethanol-ether（0.2gm/kgdaily for one

six and nine days）

the ratioof survival time as compared with the con-trol group was 155

163 and 207% respecti-vely.The toxic tests of ethanol-ether ex-tract showed that its safety coefficient wasmore than 10

and there was no obvious har-mful effect on the heart

lung

spleen

kid-ney except a slight hepatatrophic effect inmice with 0.1—0.4gm/kg/day dose for 26days.