Influences of“Tu Mao Dong Qing No.Ⅱ”（3,4-Dihydroxyacetophenone）on the Beating of Cultured Heart Cell of Neonatal Rat

Li Lianda

doi:10.13288/j.11-2166/r.1980.06.034

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Influences of“Tu Mao Dong Qing No.Ⅱ”（3,4-Dihydroxyacetophenone）on the Beating of Cultured Heart Cell of Neonatal Rat

更新时间：2021-11-20

- Influences of“Tu Mao Dong Qing No.Ⅱ”（3,4-Dihydroxyacetophenone）on the Beating of Cultured Heart Cell of Neonatal Rat
- Journal of Traditional Chinese Medicine Issue 6, Pages: 68-70(1980)
- 作者机构：
  
  1. 中医研究院西苑医院基础研究室药理组
  2. 中医研究院西苑医院基础研究室药理组本组研究生
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.1980.06.034
  CLC：
- Published：1980
- 稿件说明：
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[1]李连达,高风辉,张金妹,李映欧,张京.秃毛冬青Ⅱ号对体外培养乳鼠心肌细胞搏动的影响[J].中医杂志,1980(06):68-70+83-84.

Li Lianda. Influences of“Tu Mao Dong Qing No.Ⅱ”（3,4-Dihydroxyacetophenone）on the Beating of Cultured Heart Cell of Neonatal Rat[J]. Journal of Traditional Chinese Medicine1980, (6): 68-70.
[1]李连达,高风辉,张金妹,李映欧,张京.秃毛冬青Ⅱ号对体外培养乳鼠心肌细胞搏动的影响[J].中医杂志,1980(06):68-70+83-84. DOI： 10.13288/j.11-2166/r.1980.06.034.

Li Lianda. Influences of“Tu Mao Dong Qing No.Ⅱ”（3,4-Dihydroxyacetophenone）on the Beating of Cultured Heart Cell of Neonatal Rat[J]. Journal of Traditional Chinese Medicine1980, (6): 68-70. DOI： 10.13288/j.11-2166/r.1980.06.034.

摘要

<正> 近年来

体外培养心肌细胞用于细胞药理学、分子药理学、分子生物学以及一些基本理论的研究

进展较快

已引起广泛重视。我们自1978年建立乳鼠心肌细胞培养方法后

对附子Ⅰ号(消旋去甲乌

Abstract

The cellular pharmacological researchof an effective ingredient of Chinese medi-cinal herb on cultured neonatal rat heartcells was reported.The results showed that the3、4-Dihydroxyacetophenone（extract of Ilexpubescens Hook.et Arn.var.glaber Chang）hadcertain repressive effect on the rate

extent andstrength of the heart cell beating

as wellas some regulatory effect on its rhythm.Itshowed marked antagonistic action on theAconitine induced arrhythmia and tachycar-dia

and also had the same action on therate and rhythmic change induced by theIsoprenaline and Ouabain to some extent.The results also showed that the heart cellculture is indeed a simple and effectiveway for screening cardiovascular drugs andfurther investigating the basic theory ofwestern and traditional Chinese medicine.

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