The Antitumor Action of Yadanzi（Seed of Brucea javanica Merr.）and Its Effect on the cAMP Content of the Cancer Cells

doi:10.13288/j.11-2166/r.1980.08.034

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The Antitumor Action of Yadanzi（Seed of Brucea javanica Merr.）and Its Effect on the cAMP Content of the Cancer Cells

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- The Antitumor Action of Yadanzi（Seed of Brucea javanica Merr.）and Its Effect on the cAMP Content of the Cancer Cells
- Journal of Traditional Chinese Medicine Issue 8, Pages: 71-74(1980)
- 作者机构：
  
  1. 北京市肿瘤防治研究所药理组
  2. 北京市肿瘤防治研究所细胞生物学室
  3. 北京市肿瘤防治研究所药理组北京市肿瘤防治研究所细胞生物学室
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.1980.08.034
  CLC：
- Published：1980
- 稿件说明：
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[1]王耐勤,赵雅丽,李炜,孟松娘,汪堃仁.中药鸦胆子的抗肿瘤作用及其对癌细胞中环化一磷酸腺苷含量的影响[J].中医杂志,1980(08):71-74.

The Antitumor Action of Yadanzi（Seed of Brucea javanica Merr.）and Its Effect on the cAMP Content of the Cancer Cells[J]. Journal of Traditional Chinese Medicine1980, (8): 71-74.
[1]王耐勤,赵雅丽,李炜,孟松娘,汪堃仁.中药鸦胆子的抗肿瘤作用及其对癌细胞中环化一磷酸腺苷含量的影响[J].中医杂志,1980(08):71-74. DOI： 10.13288/j.11-2166/r.1980.08.034.

The Antitumor Action of Yadanzi（Seed of Brucea javanica Merr.）and Its Effect on the cAMP Content of the Cancer Cells[J]. Journal of Traditional Chinese Medicine1980, (8): 71-74. DOI： 10.13288/j.11-2166/r.1980.08.034.

摘要

<正> 鸦胆子系苦木科植物鸦胆子树（Brucea javanicaMerr.）的种子

药用其仁。早在18世纪中叶鸦胆子即为我国经验上治疗阿米巴痢疾的有效药物。20世纪50年代以后发现鸦胆子可用于治疗瘢痕疙瘩、鸡眼、刺瘊和乳头状瘤等疾患。近年来

国内先后发表

Abstract

In this work we have investigated theantitumor action of Chinese drug Yadanzi（Seed of Brucea javanica Merr.）10% emul-sion and the effect on cAMP content in thecancer ceils.The studies have demonstrated that Ya-danzi emulsion may induced direct killingaction on mice hepatoma cells of culture invitro.Intraperitoneal injection of 10% Ya-danzi emulsion at the dosage of 0.1 ml/10gbody weight produced a marked inhibitoryeffect on transplantable hepatoma（solid）inmice and Walker tumor 256 in rats.It alsoshowed a significant inhibitory effect on as-cites volum and cell count of mice hepato-ma（ascites）

but no effect on Ehrlich asci-（?）es carcinoma

180

and U

of mice.On theother hand

Yadanzi pretreatment may raisedwhite blood cell count in mice that haveinjectived cyclophosphamide.It did notincrease phagocytosis index

also did notinfluence the cAMP content in the hepatomacells of mice.

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