The effect of some drugs on thepulmonary metastases of the mouse hepa-toma cells have been studied.Extract fromthe root of Salvia miltiorrhiza and the rootof Paeonia lactiflora（Chishao）

when givenintraperitoneally or perorally

can greatlyenhance the pulmonary metastases of themouse hepatoma cells.Extract from the rootof Angelica sinensis and the dried flower ofcarthamus

when given intraperitoneally canalso enhance the pulmonary metastases ofhepatoma cells.Extract from Spatholobus su-berectus or Sodium ferulic acid（An activeprinciple from the root of Angelica sinen-sis）has no effect on pulmonary metastasesof hepatoma cells in mice.We have obser-ved the active component from the rhizomeof Ligusticum chuanxiong did have someinhibitory effect on pulmonary metastasesof mice in several experiments

but this ef-fect is not always reproducible

and this maybe related to its rapid metabolism in mice.Ten minutes before inoculum of tumor cells

heparin injected at the dose of 1000-2000u/kg intravenously

significantly diminishedthe nodules of pulmonary metastases.Endoxan10mg/kg given in various routes

has someinhibitory effect on the nodules of pulmon-ary metastases.