Actions of Shanhaidan V on Experimental Myocardial Ischemia in Rads

doi:10.13288/j.11-2166/r.1995.11.035

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Actions of Shanhaidan V on Experimental Myocardial Ischemia in Rads

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- Actions of Shanhaidan V on Experimental Myocardial Ischemia in Rads
- Journal of Traditional Chinese Medicine Issue 11, Pages: 689-690(1995)
- 作者机构：
  
  1. 中国人民解放军第二炮兵西安中医多学科研究所
  2. 中国人民解放军第二炮兵西安中医多学科研究所陕西省西安市西八路,710061
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.1995.11.035
  CLC： R285.5
- Published：1995
- 稿件说明：
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[1]刘毅,胡梅,曹永孝,刘德强,赵国欣.山海丹V号对大鼠实验性心肌缺血的作用[J].中医杂志,1995(11):689-690+644.

Actions of Shanhaidan V on Experimental Myocardial Ischemia in Rads[J]. Journal of Traditional Chinese Medicine1995, (11): 689-690.
[1]刘毅,胡梅,曹永孝,刘德强,赵国欣.山海丹V号对大鼠实验性心肌缺血的作用[J].中医杂志,1995(11):689-690+644. DOI： 10.13288/j.11-2166/r.1995.11.035.

Actions of Shanhaidan V on Experimental Myocardial Ischemia in Rads[J]. Journal of Traditional Chinese Medicine1995, (11): 689-690. DOI： 10.13288/j.11-2166/r.1995.11.035.

摘要

甩结扎冠脉制造大鼠心肌缺血模型

结扎冠脉15分钟后经十二指肠给药

记录给药前后心电图及用N—BT染色法定量测定结扎3小时后心肌梗塞面积。结果

山海丹Ⅴ号能在给药后15、45、65、105、165分使大鼠心率减慢（P<0.05～0.01）;结扎冠脉后15分各组ST段均明显升高

山海丹Ⅴ号1.4、2.8g/kg能明显降低ST段（P<0.01）;山海丹Ⅴ号（0.7、1.4、2.8g/kg）能减少心肌梗塞面积（P<0.01）。

Abstract

To rat model of myocardial ischemia induced by liga-tion of coronary artery. Shanhaidan V was given via duodenum 15 minutes after ligation. ECG and quantitative measurement of the area of infarction by N -BT staining 3 hours after ligation were performed before and after drug administration. Results showed’ that the heart beat rates 15. 45. 65. 105. 165 minutes after administration of Shanhaidan V were slowed down （P<0. 05 - 0. 01）. ST segment in all groups markedly elevated 15 minutes after ligation. When Shanhaidan V was given in 1. 4. 2. 8 g/kg dose

ST segment markedly lowered （P<0. 01）.

Shanhaidan V : （0. 7

1. 4. 2. 8 g/kg） also decreased the area of infarction （P<0..01）. Conclusion: Shanhaidan V ameliorated the degree of ischemia

in rat’s ischemic cardiac muscle; reduced the infarct area and slowed down rate . of heart beat.

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Related Institution

中国中医研究院西苑医院

中国中医研究院西苑医院北京市海淀区

中国人民解放军第二炮兵西安中医多学科研究所研究部

中国人民解放军第二炮兵西安中医多学科研究所研究部陕西省西安市吉祥路副54号

上海市南汇县光明中医医院中医内科上海市南汇县东门大街 339号

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