100 patients were diagnosed definitely to have atrophic gastritis （AG） with moderate - severe intestinal metaplasia （IM） and/or atypical hyperplasia （ATP） by gastroscopy and pathological examination. They were assigned at random to Wei Suo Kang treatment group and Wei Mei Su control group

50 cases in each group. Results showed that after one therapeutic course

the markedly effective rates in the two groups were 42% and 8% respectively; the total effective rates 90% and 40% （all P<0. 05）. In addition

114 Wistar rats were randomly divided into 6 groups

who taken 50mg/ml of methyl nitro - nitrosoguanidine （MNNG） solution and standard granulated feed containing 0. 01% of ranitidine for development of model of precancerous lesion

and they received treatment of Wei Suo kang and Wei Mei Su respectively. Results indicated that inflammatory cell infiltration of gastric mucosa

simple hyperplasia

IM

ATP and incidence rate of gastriccarcinoma in the treatment group were lower than those in the model group and the control group（all P < 0. 05）. Scanning electron microscopy revealed that the cellular form in the treatment group was similar to that in the blank group

with significant difference as compared with the model group and the control group. The content of DNA in nuclei

incidence rate of heteroploid

and the perimeter and the area of nuclei

and heteromorphic index of body of gland in the treatment group were significantly lower than those in the model group and the control group（all P<0. 05）.