Patients of liver cirrhosis with high blood hyaluronic acid level （>800 ng/L） and elevated NO content were enrolled to study the efficacy of treatment with a combination of drugs for heat- reducing

purgation

resolving and tonification for 6 months to 2 years. The symptoms and signs were markedly ameliorated: the level of GPT

GOT

globulin

albumin and bilirubin contents restored to normal level. In B -ultrasonographic examination

a decrease the width of the portal vein and the spleen was found in 50% of the patients. The authors concluded that the combined use of drugs for heat- reducing

purgation

resolving and tonification was effective in treating hyperhyaluronemia due to liver cirrhosis. The ingredient rhemannia root may play the key role in its actions of expelling toxic materials

normalizing the functions of the viscera and discharge of bile

and removing the stagnated heat.