Correlation Study on ET, CGRP and NO Levels in Vascular Dementia of Blood Stasis Type

doi:10.13288/j.11-2166/r.2000.09.028

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Correlation Study on ET, CGRP and NO Levels in Vascular Dementia of Blood Stasis Type

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- Correlation Study on ET, CGRP and NO Levels in Vascular Dementia of Blood Stasis Type
- Journal of Traditional Chinese Medicine Issue 9, Pages: 552-553(2000)
- 作者机构：
  
  1. 福建中医学院
  2. 福建中医学院福建省福州市五四路282号,350003
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2000.09.028
  CLC： R277.7
- Published：2000
- 稿件说明：
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[1]蔡晶,杜建.血瘀型脑血管硬化性痴呆症与内皮素、降钙素基因相关肽及一氧化氮的相关性研究[J].中医杂志,2000(09):552-553+8.

Correlation Study on ET, CGRP and NO Levels in Vascular Dementia of Blood Stasis Type[J]. Journal of Traditional Chinese Medicine2000, (9): 552-553.
[1]蔡晶,杜建.血瘀型脑血管硬化性痴呆症与内皮素、降钙素基因相关肽及一氧化氮的相关性研究[J].中医杂志,2000(09):552-553+8. DOI： 10.13288/j.11-2166/r.2000.09.028.

Correlation Study on ET, CGRP and NO Levels in Vascular Dementia of Blood Stasis Type[J]. Journal of Traditional Chinese Medicine2000, (9): 552-553. DOI： 10.13288/j.11-2166/r.2000.09.028.

摘要

选取无心、肺、肝、肾及其它脏器系统严重病变的脑血管硬化性痴呆症（VD）患者65例

根据长谷川痴呆量表评分分为轻度痴呆（VD1）组和重度痴呆（VD2）组

与正常对照组进行血瘀评分、内皮素（ET）、降钙素基因相关肽（CGRP）、一氧化氮（NO）比较。结果:（1）VD患者血瘀评分显著高于正常对照组

VD2组血瘀评分高于VD1组（P<0.01）;（2）VD组ET显著高于正常对照组

CGRP、NO显著低于正常对照组（P<0.01）;VD2组ET高于VD1组

CGRP、NO低于VD1组（P<0.01）;（3）VD患者的ET与CGRP、NO呈负相关性

CGRP与NO呈正相关性（P<0.01）;血瘀评分与ET呈正相关

与CGRP、NO呈负相关（P<0.01）。表明VD患者存在血瘀标实的病理改变

ET、CGRP、NO之间平衡制约机制的破坏在VD的发病、发展中有重要作用。

Abstract

Patients of vascular dementia （VD） without severe damage in cardinal organs were divided into group VD 1 （mild dementia） and VD 2 （severe dementia） according to the Kasagawa’s dementia scale and compared their blood stasis score

endothelin （ET）

calcitonin gene - related peptide （CGRP） and NO content with normal subjects. It was found that the blood stasis score and ET in VD were higher than that of the normal subjects and that in VD2 were higher than in VD 1 OP <0. 01). In contrary

the content of CGRP and NO were significantly lower （all P<0. 01）. ET in VD was negatively correlated with CGRP and NO; while the CGRP is positively correlated with the NO （P<0. 01）. The blood stasis score was positively correlated with the ET

but negatively with the CGRP and NO （P<0. 01）. The authors concluded that the blood stasis in VD is of excess in superficiality and the imbalance in ET

CGRP and NO is an important factor in occurrence and development of VD.

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