A Quantitative Analysis of 5 - hydroxytryptamine and Neropinephrine Content in the Brain, Hypophysis and Adrenals in Cold - deficiency Rats Administered with Drugs Warm and Hot in Properties

doi:10.13288/j.11-2166/r.2000.10.032

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A Quantitative Analysis of 5 - hydroxytryptamine and Neropinephrine Content in the Brain, Hypophysis and Adrenals in Cold - deficiency Rats Administered with Drugs Warm and Hot in Properties

更新时间：2021-11-20

- A Quantitative Analysis of 5 - hydroxytryptamine and Neropinephrine Content in the Brain, Hypophysis and Adrenals in Cold - deficiency Rats Administered with Drugs Warm and Hot in Properties
- Journal of Traditional Chinese Medicine Issue 10, Pages: 623-625(2000)
- 作者机构：
  
  1. 首都医科大学病理解剖学教研室
  2. 北京医科大学中西医结合研究室北京市右安门外西头条10号,100054
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2000.10.032
  CLC： R285
- Published：2000
- 稿件说明：
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[1]李良,刘国贞,梁月华.虚寒证鼠服温热药后脑、垂体和肾上腺内5—羟色胺及去甲肾上腺素神经元和神经纤维的变化[J].中医杂志,2000(10):623-625+8.

A Quantitative Analysis of 5 - hydroxytryptamine and Neropinephrine Content in the Brain, Hypophysis and Adrenals in Cold - deficiency Rats Administered with Drugs Warm and Hot in Properties[J]. Journal of Traditional Chinese Medicine2000, (10): 623-625.
[1]李良,刘国贞,梁月华.虚寒证鼠服温热药后脑、垂体和肾上腺内5—羟色胺及去甲肾上腺素神经元和神经纤维的变化[J].中医杂志,2000(10):623-625+8. DOI： 10.13288/j.11-2166/r.2000.10.032.

A Quantitative Analysis of 5 - hydroxytryptamine and Neropinephrine Content in the Brain, Hypophysis and Adrenals in Cold - deficiency Rats Administered with Drugs Warm and Hot in Properties[J]. Journal of Traditional Chinese Medicine2000, (10): 623-625. DOI： 10.13288/j.11-2166/r.2000.10.032.

摘要

为了研究用温阳及补气两种温热药治疗虚寒证大鼠后

其脑及肾上腺内5—羟色胺（5—HT）及去甲肾上腺素（NE）神经元以及垂体内神经纤维的递质含量变化

采用免疫组织化学的方法进行神经元及纤维形态学观察及定量分析

用荧光测定法测量脑内两种递质的含量。结果温阳与补气药均使全脑的5—HT细胞及纤维着色变浅

NE细胞及纤维的染色加深。垂体内NE纤维递质含量增多

5—HT递质含量减少。肾上腺髓质内变化不明显。全脑的NE含量增加而5—HT的含量减少。说明温阳、补气药均能提高脑各区NE神经元递质的合成释放

并抑制5—HT的合成释放

两类药物作用效果无明显差别

上述的形态学改变与机能变化一致。

Abstract

Content of the neurotransmitters 5 - Hydroxytryptamine （5 -HT） and Norepinephrine （NE） in the neurons of the brain and adrenals and in the nerve fibers of the hypophysis after administration of drugs warm and hot in properties in the cold - deficiency rats were studied immunohistochemically and fluorimetrically. The results showed that both drugs for warming yang and replenishing qi could similarly increase the content of norepinephrine and decrease the content of 5 -hydroxytryptamine in the neurons in the brain and in the nerve fibers of the hypophysis. Their content in the adrenal medulla did not show significant change.

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