Four hundred and five cases of female climacteric syndrome were randomly divided into treatment group （205 cases）

control group （100 cases） and open group （100 cases）. The treatment group was administrated orally 4 Geng Nian Qing Capsules and 4 analog starch tablets

3 times each day. The control group

4 pieces of Geng Nian An and 4 analog starch tablets

3 times each day. The open group

only 4 Geng Nian Qing Tablets

3 time daily. The courses in the 3 groups were 30 days. Clinical symptoms and laboratory indixes were observed before and after treatment. Results showed that the total effective rate was 96. 10%

the markedly effective rate was 65.36%

estradiol （E2） increased （P < 0. 001）. folliculc -stimulating hormone （FSH ）

luteotropic hormone （LH ） decreased slightly （P>0. 05）

vaginal scaling cell mature index （MI） increased （P<0. 01）

and clinical symptom cumulative scores decreased significantly (P < 0. 01 or P < 0. 001 S. Abnormal safty index did not be found in the treatment group. The total effective rate was 86%. the markedly effective rate 40%

E2 increased （P < 0. 05）

FSH and LH did not change significantly （P > 0. 05）

MI increased （P < 0. 01）. clinical symptom cumulative score decreased significantly （P<10. 01） in the control group. The total effective rate was 99%. the markedly effective rate was 66%

E2 increased （P<0. 001）

FSH and LH did not have significant change （P>0. 05）

MI increased （P < 0. 05）

clinical symptom cumulative score decreased significantly （P<0. 001） in the open group. There was significantly difference between the treatment group and the control group （P < 0. 01）

and no significant difference between the treatment group and the open group （P>0. 05）. suggesting that Geng Nian Qing Capsule can increase E

level and it is effective and safe for treatment of female climacteric syndrome.