Study on Correlativity of HLA - DQA1 Allelic Gene with Varied TCM Constitution Types in Acute Cerebral Infarction

doi:10.13288/j.11-2166/r.2001.04.032

您当前的位置：

首页 >

文章列表页 >

Study on Correlativity of HLA - DQA1 Allelic Gene with Varied TCM Constitution Types in Acute Cerebral Infarction

更新时间：2021-11-20

- Study on Correlativity of HLA - DQA1 Allelic Gene with Varied TCM Constitution Types in Acute Cerebral Infarction
- Journal of Traditional Chinese Medicine Issue 4, Pages: 237-238(2001)
- 作者机构：
  
  1. 北京中医药大学附属护国寺中医医院内科
  2. 北京大学医学部附属人民医院中心实验室
  3. 北京大学医学部附属人民医院中心实验室北京市西城区棉花胡同83号,100035
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2001.04.032
  CLC： R277.7
- Published：2001
- 稿件说明：
移动端阅览
[1]沈乃莹,闫征,金宇安,韩静,何培英,王申五.HLA—DQA1等位基因与急性脑梗塞多种中医体质类型的相关性研究[J].中医杂志,2001(04):237-238+196.

Study on Correlativity of HLA - DQA1 Allelic Gene with Varied TCM Constitution Types in Acute Cerebral Infarction[J]. Journal of Traditional Chinese Medicine2001, (4): 237-238.
[1]沈乃莹,闫征,金宇安,韩静,何培英,王申五.HLA—DQA1等位基因与急性脑梗塞多种中医体质类型的相关性研究[J].中医杂志,2001(04):237-238+196. DOI： 10.13288/j.11-2166/r.2001.04.032.

Study on Correlativity of HLA - DQA1 Allelic Gene with Varied TCM Constitution Types in Acute Cerebral Infarction[J]. Journal of Traditional Chinese Medicine2001, (4): 237-238. DOI： 10.13288/j.11-2166/r.2001.04.032.

摘要

对急性脑梗塞多种中医体质进行HLA—DQA1等位基因分型

分析体质类型的遗传易感性及体质与“证”和治疗的密切关系。采用PCR—SSP技术对观察组急性脑梗塞阴虚质、阳虚质、气虚质、痰湿质、血瘀质共103例及正常质对照组99例进行HLA—DQA1等位基因的基因分型。结果表明

HLA—DQA1*0501基因型在阴虚质明显高于正常质对照组（P<0.01）

HLA-DQA1*0301基因型在气虚质、痰湿质、血瘀质均明显高于正常质对照组（P<0.01）。提示急性脑梗塞患者

HLA—DQA1*0501基因与阴虚质相关联;HLA—DQA1*0301基因与气虚质、痰湿质及血瘀质相关联;从分子生物学水平阐明了体质与“证”

体质与“同病异治”的遗传学背景。

Abstract

Varied TCM constitutions in the patient of acute cerebral infarction were classifyed by using HLA - DQAl allehc gene to analyze hereditary susceptibility of constitution types and relation among constitution

syndrome and treatment. PCR-SSP technique was used for classification of Yin - deficiency Yang - deficiency

Qi - deficiency

phlegm - dampness and blood stasis constitution in 103 cases of acute cerebral infarction and HLA - DQAl allelic gene was used for gent classification in 99 cases of nomal constituion. Results indicated that HLA -DQA * 0501 gene type in Yin -deficiency constitution was significant higher than that of normal constitution CP<0. 01) : HLA -DQAl * 0301 gene type in Qi - deficiency

phlegm - dampness and blood stasis constitution all was higher than normal constitution （P <-0. 01）. It is suggested that HLA - DQAl * 0501 gene is correlated with Yin - deficiency in the patient of acute cerebral infarction. Thus

genetical background of relation of constitution with syndrome

and constitution with " treating the same disease with different methods" are explained from view of point of molecular biology.

关键词

Keywords

references

查看原文

Views

263

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Construction and Application of a Real-World Cohort of Community-Acquired Pneumonia Based on a Multimodal Large-Scale Traditional Chinese Medicine Big Data Platform

Efficacy and Economic Evaluation of Weishi Qingjin Formula （苇石清金方）in the Treatment of Adult Community-Acquired Pneumonia with Phlegm-Heat Obstructing the Lung Syndrome：A Multicenter Retrospective Real-World Cohort Study

Exploring the Comorbidity Mechanism，Prevention and Treatment Strategies of Rheumatoid Arthritis with Coronary Atherosclerotic Heart Disease Based on Collateral Disease Theory

Similarities and Differences between Myofascial Trigger Points and Sinew Knot：from the Perspective of the Channel Sinew Theory

Current Status and Strategic Recommendations for Randomized Controlled Trials on Functional Dyspepsia-Irritable Bowel Syndrome Comorbidity：from a Real-World Research Perspective

Related Author

No data

Related Institution

No data

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰