Effects of Lu Jiao Fang on Myocardial Fibrosis and Plasma Aldosterone Content in the Rat with Increase of PressureLoading

doi:10.13288/j.11-2166/r.2001.06.031

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Effects of Lu Jiao Fang on Myocardial Fibrosis and Plasma Aldosterone Content in the Rat with Increase of PressureLoading

更新时间：2021-11-20

- Effects of Lu Jiao Fang on Myocardial Fibrosis and Plasma Aldosterone Content in the Rat with Increase of PressureLoading
- Journal of Traditional Chinese Medicine Issue 6, Pages: 363-365(2001)
- 作者机构：
  
  1. 河北医科大学中西医结合博士后科研流动站生化教研室
  2. 上海中医药大学附属曙光医院
  3. 上海中医药大学附属曙光医院石家庄市中山东路361号,050017
  4. 河北医科大学中西医结合博士后科研流动站生化教研室上海中医药大学附属曙光医院上海中医药大学附属曙光医院石家庄市中山东路361号,050017
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2001.06.031
  CLC： R285.5
- Published：2001
- 稿件说明：
移动端阅览
[1]蔡辉,胡婉英,董耀荣,赵卫.鹿角方对压力负荷增加大鼠心肌纤维化和血浆醛固酮的影响[J].中医杂志,2001(06):363-365+324.

Effects of Lu Jiao Fang on Myocardial Fibrosis and Plasma Aldosterone Content in the Rat with Increase of PressureLoading[J]. Journal of Traditional Chinese Medicine2001, (6): 363-365.
[1]蔡辉,胡婉英,董耀荣,赵卫.鹿角方对压力负荷增加大鼠心肌纤维化和血浆醛固酮的影响[J].中医杂志,2001(06):363-365+324. DOI： 10.13288/j.11-2166/r.2001.06.031.

Effects of Lu Jiao Fang on Myocardial Fibrosis and Plasma Aldosterone Content in the Rat with Increase of PressureLoading[J]. Journal of Traditional Chinese Medicine2001, (6): 363-365. DOI： 10.13288/j.11-2166/r.2001.06.031.

摘要

为观察鹿角方对压力负荷增加大鼠心肌纤维化和血浆醛固酮的影响

以探讨其抗心肌纤维化的可能作用机制

建立腹主动脉狭窄所致充血性心力衰竭心肌肥厚大鼠模型

观察左室质量指数（LVMI）;采用免疫组织化学染色方法观察心肌Ⅰ、Ⅲ型胶原的改变;采用放射免疫分析方法检测血浆醛固酮（Ald）水平的改变。结果模型组LVMI明显高于假手术组（P<0.001）

鹿角方组LVMI较模型组明显下降（P<0.01）;模型组Ⅰ型胶原较假手术组显著升高（P<0.01）

鹿角方组较模型组明显下降（P<0.01）;模型组Ⅲ型胶原较假手术组显著升高（P<0

01）

鹿角方组较模型组显著下降（P<0.01）;模型组血浆醛固酮水平较假手术组显著升高（P<0.001）

鹿角方组明显降低血浆醛固酮水平（P<0.001）。证明压力负荷增加大鼠血浆醛固酮水平是升高的;鹿角方具有逆转该大鼠心肌纤维化的作用

该作用可能与降低血浆醛固酮水平有关。

Abstract

Effects of Lu Jiao Fang on myocardial fibrosis and plasma aldosterone （ALD） content in the rat with increase of pressure - loading were investigated for approach to the machanism of anti - myocardial fibrosis. Left ventricular mass index（LVMI）

myocardial collagen Ⅰ

Ⅱ Ⅲ and plasma ALD content were observed. Results showed that LVMI in the model group was significantly higher than that in the sham operation group（P<0. 001）

in the Lu Jiao Fang group was lower than that in the model group （P<0. 01） ; Collagen I in the model group increased significantly （P<0. 01） as compared with that in the sham operation group

and in the Lu Jiao Fang group was lower than that in the model group （P<0. 01） : Plasma ALD content in the model group was higher than that in the sham operation group （P<0. 001）

and it was decreased in the Lu Jiao Fang group （P<0. 001）. It is proved that plasma ALD level in the rat with increase of pressure - loading enhances; Lu Jiao Fang has against myocardial fibrosis of the rat

which may be related with the decrease of plasma ALD level.

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