Effects of Stimulation of Wind, Cold and Dampness on Metabolism of Oxygen Free Radical and Prostaglandin in Cervical Muscle and Blood in Rabbits

doi:10.13288/j.11-2166/r.2001.08.025

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Effects of Stimulation of Wind, Cold and Dampness on Metabolism of Oxygen Free Radical and Prostaglandin in Cervical Muscle and Blood in Rabbits

更新时间：2021-11-20

- Effects of Stimulation of Wind, Cold and Dampness on Metabolism of Oxygen Free Radical and Prostaglandin in Cervical Muscle and Blood in Rabbits
- Journal of Traditional Chinese Medicine Issue 8, Pages: 489-490(2001)
- 作者机构：
  
  1. 暨南大学医学院中医学系
  2. 上海中医药大学骨伤科研究所广东省广州市石牌,510632
  3. 暨南大学医学院中医学系上海中医药大学骨伤科研究所广东省广州市石牌,510632
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2001.08.025
  CLC： R255.6
- Published：2001
- 稿件说明：
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[1]姜杰,施杞.风寒湿刺激对家兔颈部肌肉及血液组织中氧自由基和前列腺素代谢的影响[J].中医杂志,2001(08):489-490+8.

Effects of Stimulation of Wind, Cold and Dampness on Metabolism of Oxygen Free Radical and Prostaglandin in Cervical Muscle and Blood in Rabbits[J]. Journal of Traditional Chinese Medicine2001, (8): 489-490.
[1]姜杰,施杞.风寒湿刺激对家兔颈部肌肉及血液组织中氧自由基和前列腺素代谢的影响[J].中医杂志,2001(08):489-490+8. DOI： 10.13288/j.11-2166/r.2001.08.025.

Effects of Stimulation of Wind, Cold and Dampness on Metabolism of Oxygen Free Radical and Prostaglandin in Cervical Muscle and Blood in Rabbits[J]. Journal of Traditional Chinese Medicine2001, (8): 489-490. DOI： 10.13288/j.11-2166/r.2001.08.025.

摘要

为了探讨颈部风寒湿刺激对机体氧自由基及前列腺素的影响

将24只新西兰大白兔随机分为正常对照组、风寒湿组、低头位组、复合模型组4组

每组6只。通过给予风寒湿、低头位刺激

观察受累局部和血液组织中超氧化物歧化酶（SOD）、脂质过氧化物（LPO）、前列腺素E

（PGE

）、6-酮-前列腺素F

1α

(6-keto-PGF

1α

)的变化。结果表明

风寒湿与低头位等颈椎病常见的致病因素可使颈部出现无菌性炎症并使受累局部组织和血液中SOD、LPO、PGE

、6-keto-PGF

1α

出现异常。氧自由基及前列腺素代谢异常可能是风寒湿致颈椎病的重要机理之一。

Abstract

In order to probe into effect of stimulation of wind

cold and Sdampness to the cervical part on oxygen free radical and prostaglandins

24 rabbits were randomly assigned to control group and wind - cold - Sdampness group

head - lowering group and combined model group

6 rabbits in each group

and changes of superoxide dismutase （SOD）

lipid hyperoxide （LPO）

prostanglandin E2 （PGE2）

6 -keto -PGF1a in affected local region and blood were observed. Results indicated that the commonly - seen pathogenetic factors of cervical spondylopathy such as wind

cold

dampness and lowering head might cause aspetic inflammation of the cervical part and abnormality of SOD

LPO

PGE2 and 6 - keto - PGF1a in affected local tissue and blood

and abnormal metabolism of oxygen free radical and prostagnadins might be one of important mechanisms of cervical spondylopathy induced by wind

cold and dampness.

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Institute of Integrated Chinese and Western Medicine,First Hospital of Peiking Univerrsity

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