In order to approach the mechanisms of Chinese drug Bu Sui Sheng Xue Instant Granules for tonifying kidney inhibiting apoptosis in the patient of chronic aplastic anemia （CAA）

levels of soluble Fas （sFas）

tumor necrosis factor （TNF-a）

interleukin - 2 （IL - 2） before and after treatment were determined in 30 cases of CAA and Zai Zang Sheng Xue Tablet was used as control. Results indicated that expression of serum sFas

TNF - a and IL - 2 before treatment was significantly higher than those of the control group （P<0. 05

P<0. 01）

and after treatment the levels of sFas and TNF -a approached to the normal （P>0. 05）

and the IL-2 level still was higher than the normal （P<0. 05）. It is suggested that there is abnormal expression of correlative factors of apoptosis in serum of the patient of CAA; Bu Sui Sheng Xue controls expression of Fas on the surface of cells and influences expression of serum sFas in the patient of CAA through regulating TNF - a level

and apoptosis of CAA is influenced not through regulating expression of IL - 2.