Cytologic Study on Prevention and Treatment of Primary Osteoporosis with Chinese Drugs for Tonifying the Kidney

doi:10.13288/j.11-2166/r.2001.10.028

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Cytologic Study on Prevention and Treatment of Primary Osteoporosis with Chinese Drugs for Tonifying the Kidney

更新时间：2021-12-19

- Cytologic Study on Prevention and Treatment of Primary Osteoporosis with Chinese Drugs for Tonifying the Kidney
- Journal of Traditional Chinese Medicine Issue 10, Pages: 621-623(2001)
- 作者机构：
  
  1. 上海中医药大学附属曙光医院骨伤科
  2. 浙江中医学院
  3. 上海市中医药研究院骨伤科研究所
  4. 上海市中医药研究院骨伤科研究所上海市普安路185号,200021
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2001.10.028
  CLC： R259.8
- Published：2001
- 稿件说明：
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[1]石印玉,詹红生,赵咏芳,沈培芝,徐宇.补肾中药防治原发性骨质疏松症的细胞学研究[J].中医杂志,2001(10):621-623+8.

Cytologic Study on Prevention and Treatment of Primary Osteoporosis with Chinese Drugs for Tonifying the Kidney[J]. Journal of Traditional Chinese Medicine2001, (10): 621-623.
[1]石印玉,詹红生,赵咏芳,沈培芝,徐宇.补肾中药防治原发性骨质疏松症的细胞学研究[J].中医杂志,2001(10):621-623+8. DOI： 10.13288/j.11-2166/r.2001.10.028.

Cytologic Study on Prevention and Treatment of Primary Osteoporosis with Chinese Drugs for Tonifying the Kidney[J]. Journal of Traditional Chinese Medicine2001, (10): 621-623. DOI： 10.13288/j.11-2166/r.2001.10.028.

摘要

为了比较补肾复方对成骨细胞（OB）、破骨细胞（OC）的药效异同

用MTT法测定OB增殖能力

骨陷窝计数定量评定OC骨吸收活性。结果

金匮肾气丸、补肾益精方、知柏地黄丸、西药倍美力对OB增殖的平均影响率分别为159.2％、121.5％、21.6％、75.7％;对骨陷窝数的平均影响率分别为50.2％、21.0％、19.8％、38.1％。表明平补阴阳药既促进OB增殖又抑制OC活性

加重温阳药促OB增殖作用加强

加重养阴药的作用则相反

养阴并加入泻火药则对OC活性和OB增殖均表现为抑制。

Abstract

In order to compare differences of effects of complex prescription for reinforcing the kidney on osteoblast （OB） and osteoclast （OC）

MTT method was used to determine proliferous capability of OB

bone lacuna count was used for quantitative assessment of absorbent activity of OC. Results showed that the mean influencing rate of Jin Gui Shen Qi Pill

Bu Shen Yi Jing Prescription

Zhi Bai Di Huang Pill

and Western medicine Premarin tablet for proliferous capability of OB was 159. 2%

121. 5%

21. 6% and 75. 7% respectively; the mean influencing rate for bone lacuna count was 50. 2%

21. 0%

19. 8% and 38. 1% respectively

suggesting that the drug for even reinforcing Yin and Yang can improve proliferation of OB and inhibit activity of OC

and increase of the drug for warming Yang can strengthen the promoting action on proliferation of OB

but increase of the drug for nourishing Yin had opposed action

the drugs for nourishing Yin plus the drugs for purging the pathologic fire can inhibit activity of OC and proliferation of OB.

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