Clinical study on treatment of 25 cases of hepatic fibrosis after hepatitis B With Ruan Can Mixure combined with interferon

doi:10.13288/j.11-2166/r.2002.10.026

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Clinical study on treatment of 25 cases of hepatic fibrosis after hepatitis B With Ruan Can Mixure combined with interferon

更新时间：2021-11-20

- Clinical study on treatment of 25 cases of hepatic fibrosis after hepatitis B With Ruan Can Mixure combined with interferon
- Journal of Traditional Chinese Medicine Issue 10, Pages: 753-754(2002)
- 作者机构：
  
  1. 中国人民解放军兰州军区兰州总医院中医科
  2. 中国人民解放军第一○七中心医院中医肿瘤科
  3. 西安医科大学第二附属医院兰州市七里河区58号,730050
  4. 中国人民解放军兰州军区兰州总医院中医科中国人民解放军第一○七中心医院中医肿瘤科西安医科大学第二附属医院兰州市七里河区58号,730050
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2002.10.026
  CLC： R512.62
- Published：2002
- 稿件说明：
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[1]燕忠生,沈吉云,赵淑媛.软肝合剂联合干扰素治疗乙肝后肝纤维化25例临床研究[J].中医杂志,2002(10):753-754+5.

Clinical study on treatment of 25 cases of hepatic fibrosis after hepatitis B With Ruan Can Mixure combined with interferon[J]. Journal of Traditional Chinese Medicine2002, (10): 753-754.
[1]燕忠生,沈吉云,赵淑媛.软肝合剂联合干扰素治疗乙肝后肝纤维化25例临床研究[J].中医杂志,2002(10):753-754+5. DOI： 10.13288/j.11-2166/r.2002.10.026.

Clinical study on treatment of 25 cases of hepatic fibrosis after hepatitis B With Ruan Can Mixure combined with interferon[J]. Journal of Traditional Chinese Medicine2002, (10): 753-754. DOI： 10.13288/j.11-2166/r.2002.10.026.

摘要

目的:观察软肝合剂联合干扰素对乙型肝炎及肝纤维化的治疗作用。方法:所有观察对象随机分为治疗组（用软肝合剂联合干扰素治疗）和对照组（用干扰素治疗）

观察两组间治疗前后HBV—DNA、HBeAg、肝功能、血清透明质酸（HA）、Ⅳ型胶原（Ⅳ-C）、层粘蛋白（LN）水平变化情况。结果:两药联用较对照组在HBV—DNA及HBeAg转阴率方面差异无显著性（P>0.05）

治疗组天冬氨酸转氨酶（AST）、丙氨酸氨基转氨酶（ALT）下降较对照组差异有非常显著性（P<0.01）

治疗组血清HA、IV—C、LN水平下降程度较对照组差异有非常显著性（P<0.01）。结论:软肝合剂联用干扰素在抗病毒方面无协同增效作用

而在保肝、抗纤维化方面有协同增效作用。

Abstract

Purpose: To observe on therapeutic action of Ruan Gan Mixture combined with interferon on hepatitis B and hepatic fibrosis. Methods: The cases were randomly divided into the treatment group treated with Ruan Gan Mixture combined with interferon

and the control group treated with interferon

and HBV-DNA. HBeAg. hepatic function

serum HA. IV - C and LN levels before and after treatment were observed. Results. Aspartate aminotransfera.se （AST）. Alanine aminotransferase （ALT）

and serum HA. IV - C and LN levels in the treatment group decreased significantly （P < 0. 01）

but HBV - DNA. and HBeAg negative - turning rate did not significantly change in the treatment group as compared with the control group （P>0. 05）. Conclusion: Ruan Gan Mixture combined interferon have cooperative effect - increasing action in protective liver and anti - fibrosis.

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