Objective: To investigate the effect of Fu Zheng Hua Yu-319 Recipe on hepatic sinusoid capillarization in the rat of hepatic fibrogenesis. Methods: Hepatic fibrosis model rats were induced by intraperitoneal injection of dimethyl nitrosamine （DMN）. thrice a week for 4 weeks

and they were divided into the treatment group which were treated with Fu Zheng Hua Yu-319 Recipe for 4 weeks

and the model control group. Serum and hepatic tissue were taken for examination of pathohistology

microstructure by electron microscopy

immunohistochemistry

and hydroxyproline content in the liver tissue and hepatic function. Results: In the normal group

peripheral cytoplasma of endothelial cells in the hepatic sinusoid is very thin with a lot of small fenestra

and no basement membrane under endothelium was found. In the model group

crookedness and stricture of the hepatic sinusoid were found

and the fenestra in cytoplasma of the endothelial cell reduced or disappeared with obvious basement membrane

and hemorrhage necrosis in the liver tissue could be found

with a great proliferation of connective tissue in the portal area

and fibrous septum extended towards into the lobuli

the content of hydroxyproline （HYP） in the liver tissue increased significantly. The VI factor-related antigen

a-actin of smooth muscle

LM and type IV collagen positive staining on the hepatic sinusoid wall increased significantly with a wider range as compared with the normal rat. In the treatment group

the extents of crookedness and stricture of hepatic sinusoid and reduction and disappearence of endothelial fenestra were lower

with thiner or discontinuous basement membrane

and a part of hepatic sinusoid construction approached to normal

and degeneration and necrosis of hepatic cells were mild and fibrous septum in the liver tissue decreased significantly

and HYP content decreased significantly （P < 0.05）

and the VI factor-related antigen

a-actin of smooth muscle

LM and type IV collagen positive staining on the hepatic sinusoid walls weakened significantly

with significant decrease in the image analysis results of distribution area （P<0. 05）. Conclusion: The Fu Zheng Hua Yu Recipe can effectively inhibit experimental hepatic fibrosis and sinusoid capillarization.