Objective: To explore the mechanism of changes of intestinal mucosal barrier function and protective action of Compound Dachengqi Decoction on intestinal mucosal barrier function in the patient of excess syndrome of Yangming Fu-organs. Methods: 20 cases of excess syndrome of Yangming Fu-organs were randomly divided into 2 groups. One group was treated by routine method

and another was treated by Chinese herbs Compound Dachengqi Decoction on the basis of routine treatment

for 5 consecutive days. Blood diamine oxidase （DAO） activity and endotoxin （ET） content

the ratio of urine excretion rates of milk fructose and mannitol （M/L） and intestinal mucosal permeability were investigated. Additionally

10 healthy subjects were used as normal control group. Results: As compared with the control group. M/L ratio in urine

blood DAO activity and ET content in the patient of excess syndrome of Yangming Fu-organs significantly increased. After treatment by Compound Dachengqi Decoction

all the above mentioned indexes significantly decreased （P<0.01）. Conclusion: In the patient of excess syndrome of Yangming Fu-organs. intestinal mucosa is injured and the intestinal mucosal permeability increases

and Compound Dachengqi Decoction can decrease the intestinal mucosal permeability. protect intestinal mucosal barrier function and effectively decrease blood endotoxin content.