Experimental Study on Correlativity of Damp-heat Quantification in Damp-Heat Syndrome of Epidemic Febrile Disease

doi:10.13288/j.11-2166/r.2003.09.035

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Experimental Study on Correlativity of Damp-heat Quantification in Damp-Heat Syndrome of Epidemic Febrile Disease

更新时间：2021-11-22

- Experimental Study on Correlativity of Damp-heat Quantification in Damp-Heat Syndrome of Epidemic Febrile Disease
- Journal of Traditional Chinese Medicine Issue 9, Pages: 688-690(2003)
- 作者机构：
  
  1. 中国人民解放军第一军医大学中医系
  2. 中国人民武装警察部队广东省总队医院
  3. 广州中医药大学
  4. 第一军医大学南方医院广州市同和,510515
  5. 级博士,2001
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2003.09.035
  CLC： R254
- Published：2003
- 稿件说明：
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[1]吴仕九,廖礼兵,文小敏,徐萌.温病湿热证湿热量化的相关性实验研究[J].中医杂志,2003(09):688-690+5.

Experimental Study on Correlativity of Damp-heat Quantification in Damp-Heat Syndrome of Epidemic Febrile Disease[J]. Journal of Traditional Chinese Medicine2003, (9): 688-690.
[1]吴仕九,廖礼兵,文小敏,徐萌.温病湿热证湿热量化的相关性实验研究[J].中医杂志,2003(09):688-690+5. DOI： 10.13288/j.11-2166/r.2003.09.035.

Experimental Study on Correlativity of Damp-heat Quantification in Damp-Heat Syndrome of Epidemic Febrile Disease[J]. Journal of Traditional Chinese Medicine2003, (9): 688-690. DOI： 10.13288/j.11-2166/r.2003.09.035.

摘要

目的;为探讨温病湿热证湿热量化的实验方法

在以往研究基础上

筛选出相关性强的量化指标。方法;通过复制湿热证动物模型

采用Bradford方法测定水通道蛋白2（AQP2）含量

放免法检测内皮素（ET）、降钙素基因相关肽（CGRP）

一步双抗夹心酶联免疫法检测粒细胞集落刺激因子（G-CSF）

比色法检测中分子（MMS）和巯基（R-SH）物质等。结果;湿热证模型组AQP2水平较正常组明显降低

用清香散治疗后AQP2水平基本恢复正常

与正常组接近。湿热模型组ET水平较正常对照组明显升高

而CGRP较正常组降低（P<0.01）。湿热证模型大鼠血中G-CSF、MMS升高

而R-SH水平降低

经清香散治疗1周后.大鼠血中G-CSF、MMS及R-SH基本恢复正常

模型对照组G-CSF阳性率升高。结论;AQP2与ET、CGRP、G-CSF、R-SH、MMS分别可作为“湿”偏重

“热”偏重

“湿热病因”的相关性量化指标。这些技术指标对湿热定性、量化

清热祛湿药物的研究以及湿热证“证”本质的深入探讨有重要意义。

Abstract

Objective: To explore experimental methods for damp-heat quantification in damp-heat syndrome of epidemic febrile disease and scan highly correlative quantification indexes. Methods: AQP2. endothenin （ET ）. calcitonin-gene related peptide（CGRP） and granulocyte colony stimulating factor （G-CSF） . middle molecular substance （MMS） and hydrosulfide substances（R-SH） were determined in the damp-heat animal model. Results: AQP2 level in damp-heat model group was significantly lower than that in normal control group

and after treatment by Qingxiang Powder it was restored basically to the normal level. ET level in damp-heat model group was higher and CGRP was lower than that in normal group （P<0. 01） . Blood G-CSF and MMS increased and R-SH level decreased in the damp-heat rats. After treatment of one week by Qingxiang Powder

blood G-CSF. MMS and R-SH basically restored to normal

and G-CSF positive rate increased in model control group. Conclusion: AQP2 ET. CGRP. G-CSF. R-SH and MMS can be respectively used as correlative quantification indexes for the patient with "more dampness" . "more heat" and "the cause of disease of damp-heat".

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