Clinical Study on Jiangya Capsules for Treatment of 24 Cases of Senile Simple Systolic Hypertention

doi:10.13288/j.11-2166/r.2004.01.018

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Clinical Study on Jiangya Capsules for Treatment of 24 Cases of Senile Simple Systolic Hypertention

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- Clinical Study on Jiangya Capsules for Treatment of 24 Cases of Senile Simple Systolic Hypertention
- Journal of Traditional Chinese Medicine Issue 1, Pages: 26-28(2004)
- 作者机构：
  
  1. 河南省中医药研究院附属医院老年病科
  2. 中国中医研究院西苑医院全国中医老年病医疗中心,100091
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2004.01.018
  CLC： R259.4
- Published：2004
- 稿件说明：
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[1]李浩,刘芳,崔玲,徐立然,罗增刚.降压胶囊治疗老年单纯收缩期高血压24例临床研究[J].中医杂志,2004(01):26-28+5.

Clinical Study on Jiangya Capsules for Treatment of 24 Cases of Senile Simple Systolic Hypertention[J]. Journal of Traditional Chinese Medicine2004, (1): 26-28.
[1]李浩,刘芳,崔玲,徐立然,罗增刚.降压胶囊治疗老年单纯收缩期高血压24例临床研究[J].中医杂志,2004(01):26-28+5. DOI： 10.13288/j.11-2166/r.2004.01.018.

Clinical Study on Jiangya Capsules for Treatment of 24 Cases of Senile Simple Systolic Hypertention[J]. Journal of Traditional Chinese Medicine2004, (1): 26-28. DOI： 10.13288/j.11-2166/r.2004.01.018.

摘要

目的:探讨降压胶囊治疗老年单纯收缩期高血压（EISH）的疗效及作用机理。方法:随机双盲对照法设治疗组24例与对照组23例

治疗组服用降压胶囊及尼莫地平胶囊模拟药

对照组服用尼莫地平胶囊及降压胶囊模拟药。结果:治疗组降压疗效总有效率75.00％

对照组总有效率73.91％

治疗组总有效率稍高于对照组（P>0.05）;两组治疗4周及8周后均能明显改善收缩期血压值（P<0.01）。治疗组中医证候的总有效率为91.67％

优于对照组（P<0.05）。治疗组提高EISH患者血清一氧化氮合酶（NOS）活力、降低丙二醛（MDA）血清水平的作用优于对照组（P<0.05）

降低血浆神经Y肽（NPY）、同型半胱氨酸（Hcy）浓度的作用较对照组更为显著（P<0.01）。结论:降压胶囊对EISH有较好的疗效且无明显毒副作用

调节患者血清NOS、MDA水平及血浆NPY、Hcy浓度可能是其作用机理的一些方面。

Abstract

Objective: To explore the therapeutic effect of Jiangya Capsules on senile simple systolic hypertention and its mechanisms. Methods: The patients were randomly divided into treatment group（n = 24） and control group （n = 23）. Treatment group was treated by Jiangya Capsules and mimetic drug of Nimodipine capsules

and control group was given Nimodipine capsules and the mimetic drug of Jiangya Capsules. Results: The total effective rate for decreasing blood pressure was 75. 00% in treatment group and 73. 91% in control group

with no significant difference between the two groups （P>0. 05）. The systolic pressure was improved in two groups after treatment of 4 and 8 weeks （P <0. 01）. Total effective rate for TCM syndromes in the treatment group was 91. 66%

better than that in control group （P< 0. 05）. The increase of serum nitric oxide synthase （NOS）

and the decrease of malondialdehyde （MDA）

plasma neuropeptide Y（NPY） and homocysteine （Hcy） in treatment group were better than in control group （P<0. 05 or P<0. 01）. Conclusion: Jiangyan Capsules has a better therapeutic effect on senile simple systolic hyertention with no obvious toxic-side effects. Regulation of serum NOS activity and MDA level

and plasma NPY and Hcy contents are possiply some aspects of the mechanisms.

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