Objective: To probe mechanisms of Shenbi-ning in treatment of many kinds of nephrosis and molecular mechanisms of "treating different diseases with the same therapeutic principle ". Methods: Chronic serum disease and IgA nephrosis model rat was established

and hyperplasia of mesangium

apoptosis and Fas and PCNA expression in the mesentefic region were investigated with HE staining. TUNEL and immuno-histochemical methods

respectively. Results: Shenbi-ning could improve Fas expression

reduce pathological lesion which was positively correlated with the apoptosis rate for the two membranous types with significant difference between treatment group and model group （P<0. 05）. Conclusion: Shenbi-ning treats many kinds of diseases through controlling Fas expression in the mesenteric region

inducing apoptosis in the mesentery and inhibit its hyperplasia; and molecular basis of "treating different diseases with the same therapeutic principle" is possibly that a same drug regulates same genes of different diseases.