Study on Relation between Chronic Superficial Gastritis （Spleen and Stomach Damp-Heat syndrome） and Aquaporin 4 Expression

Zhou Zheng. Lao Shaoxian. Huang Zhixin. et al. The First Affiliated Hospital . Guangzhou University of TCM. Guangzhou 510405

doi:10.13288/j.11-2166/r.2004.05.037

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Study on Relation between Chronic Superficial Gastritis （Spleen and Stomach Damp-Heat syndrome） and Aquaporin 4 Expression

更新时间：2021-11-20

- Study on Relation between Chronic Superficial Gastritis （Spleen and Stomach Damp-Heat syndrome） and Aquaporin 4 Expression
- Journal of Traditional Chinese Medicine Issue 5, Pages: 371-372(2004)
- 作者机构：
  
  1. 广州中医药大学第一附属医院脾胃消化病治疗中心
  2. 广州中医药大学第二临床医学院
  3. 广州中医药大学第一附属医院病理科广州市机场路12号,510405
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2004.05.037
  CLC： R259.7
- Published：2004
- 稿件说明：
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[1]周正,劳绍贤,黄志新,黄烈平,张向菊,匡忠生.慢性浅表性胃炎(脾胃湿热证)与水通道蛋白4表达关系的研究[J].中医杂志,2004(05):371-372+5.

Zhou Zheng. Lao Shaoxian. Huang Zhixin. et al. The First Affiliated Hospital . Guangzhou University of TCM. Guangzhou 510405. Study on Relation between Chronic Superficial Gastritis （Spleen and Stomach Damp-Heat syndrome） and Aquaporin 4 Expression[J]. Journal of Traditional Chinese Medicine2004, (5): 371-372.
[1]周正,劳绍贤,黄志新,黄烈平,张向菊,匡忠生.慢性浅表性胃炎(脾胃湿热证)与水通道蛋白4表达关系的研究[J].中医杂志,2004(05):371-372+5. DOI： 10.13288/j.11-2166/r.2004.05.037.

Zhou Zheng. Lao Shaoxian. Huang Zhixin. et al. The First Affiliated Hospital . Guangzhou University of TCM. Guangzhou 510405. Study on Relation between Chronic Superficial Gastritis （Spleen and Stomach Damp-Heat syndrome） and Aquaporin 4 Expression[J]. Journal of Traditional Chinese Medicine2004, (5): 371-372. DOI： 10.13288/j.11-2166/r.2004.05.037.

摘要

目的:从水波代谢来研究脾胃湿热证与水通道蛋白4（AQP4）表达的关系。方法:慢性浅表性胃炎患者32例

其中脾胃湿热证20例

脾气虚证12例;另10例正常人为对照。胃镜下取胃体上部粘膜

观察粘膜炎症情况

用免疫组化祛、图像分析系统半定量AQP4的蛋白表达量。结果:脾胃湿热证胃粘膜的炎症明显要重于脾虚证和正常人组（P<0.05

P<0.01）;脾胃湿热证AQP4蛋白表达量强于脾虚证组（P<0.01）和正常人组（P<0.05）;脾虚证蛋白表达量低于正常人组

但两组差异无显著性（P>0.05）。结论:AQP的异常表达可能是脾胃湿热证的发生机制之一。

Abstract

Objective: To study relation between spleen and stomach damp-heat syndrome and aquaporin 4 （AQP4） expression. Methods: 32 cases of superficial gastritis including 20 cases of spleen and stomach damp-heat syndrome and 12 cases of spleen Qi-deficiency syndrome

and 10 normal persons were investegated. Results: Inflammation of gastric mucosa in the spleen and stomach damp-heat syndrome group was significantly more severe than that in the spleen deficiency group and the normal person group （P<0. 05. P<0. 01）; AQP4 expression in the spleen and stomach damp-heat syndrome group was stronger than that in the spleen deficiency group （P < 0. 01） and the normal person group （P < 0. 05）. Conclusion: Abnormal expression of AQP4 is possibly one of the mechanisms of spleen and stomach damp-heat syndrome.

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Related Institution

The First Affiliated Hospital of Sun Yat-Sen University

Institute of Spleen and Stomach,Guangzhou University of TCM

广东省中医院

中山大学达安基因诊断中心广州市中山二路58号

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