Study on Correlativity of TCM Syndrome Types of Chronic Aplastic Anemia with MHC-DRB1*Allelic Genes

doi:10.13288/j.11-2166/r.2004.06.033

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Study on Correlativity of TCM Syndrome Types of Chronic Aplastic Anemia with MHC-DRB1*Allelic Genes

更新时间：2021-11-20

- Study on Correlativity of TCM Syndrome Types of Chronic Aplastic Anemia with MHC-DRB1*Allelic Genes
- Journal of Traditional Chinese Medicine Issue 6, Pages: 450-452(2004)
- 作者机构：
  
  1. 黑龙江中医药大学附属第一医院血液科
  2. 黑龙江中医药大学中药教研室哈尔滨市动力区和平路26号,150040
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2004.06.033
  CLC： R259.5
- Published：2004
- 稿件说明：
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[1]孙伟正,杨东光,刚宏林.慢性再生障碍性贫血中医辨证分型与MHC-DRB1*等位基因的相关性研究[J].中医杂志,2004(06):450-452+404.

Study on Correlativity of TCM Syndrome Types of Chronic Aplastic Anemia with MHC-DRB1*Allelic Genes[J]. Journal of Traditional Chinese Medicine2004, (6): 450-452.
[1]孙伟正,杨东光,刚宏林.慢性再生障碍性贫血中医辨证分型与MHC-DRB1*等位基因的相关性研究[J].中医杂志,2004(06):450-452+404. DOI： 10.13288/j.11-2166/r.2004.06.033.

Study on Correlativity of TCM Syndrome Types of Chronic Aplastic Anemia with MHC-DRB1*Allelic Genes[J]. Journal of Traditional Chinese Medicine2004, (6): 450-452. DOI： 10.13288/j.11-2166/r.2004.06.033.

摘要

目的:探讨慢性再生障碍性贫血中医辨证与MHCDRB1*等位基因多态性之间的关系。方法:采用聚合酶链式反应/序列特异性引物的技术方法

对慢性再生障碍性贫血（CAA）患者和对照组的MHC-DRB1*各等位基因进行检测和分析。结果:肾阳虚型组患者MHC-DRB1*0301基因频率明显高于健康对照组

两组差异有非常显著性（P<0.01）。MHCDRB1*各等位基因未见与CAA肾阴虚型相关。结论:MHCDRB1*0301基因可能是CAA肾阳虚型的易感基因

或者也可能是CAA的易感基因或其一部分

表明该型患者的免疫调控缺陷遗传基础的存在。MHC与CAA的先天体质疾病类型之间有一定的内在联系

能在一定程度上反映中医体质的遗传特征和CAA中医辨证的客观性。

Abstract

Objective: To approach to relation of TCM syndrome differentiation of chronic aplastic anemia （CAA） with polymorphism of MHC-DRB1 * allelic genes. Methods: MHC-DRB1 * allelic genes in patients of CAA and healthy control group were detected and analyzed by PCR/sequence-specific primer technique. Results: MHC-DRB1 * 0301 gene frequency in the patient of kidney-Yang deficiency was significantly higher than that in the healthy control group （P<0. 01）. MHC-DRB1 * allelic genes were not related with kidney-Yin deficiency in the patient of CAA. Conclusion: MHC-DRB1 * 0301 genes are possibly susceptible genes of kidney-Yang deficiency in the patient of CAA. or susceptible genes of CAA or a part of them

indicating that patients of this type have genetic basis of immunoregulative defect; and there is a certain inner link between MHC and disease types of congenital constitution of CAA. which can reflect genetic characteristics of TCM costitution and objectiveness of CAA TCM syndrome differentiation to a certain extent.

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