Objective: To observe therapeutic effect of the method for regulating and tonifying the kidney and removing blood stasis and toxic substance on chronic renal failure. Methods: 111 cases were divided into treatment group of 71 cases and a control group of 40 cases. They were reslectively treated with Yishen Granules and Niaoduqing. Before and after treatment

blood creatinine （SCr）

endogeneous creatinine clearance rate （Ccr）

blood urea nitrogen （BUN）. P. Ca

hemoglobin （Hb）

24-hour urine protein. total cholesterol （TC）. triglyceride （TG）. high density lipoprotein-cholesterol （HDL-C）

low density lipoprtein-cholesterol （LDL-C）. plasma endothelin （ET）. calaitonin gene related peptide （CGRP） and tumor necrosis factor-α （TNF-α） were determined. Results: In the treatment group. 38 cases were markedly effective. 23 cases were effective and 10 cases were ineffective

with a total effective rate of 85. 91%. and in the control group 2 cases were markedly effective

7 cases were effective. 11 cases were ineffective

with a total effective rate of 72. 5%. There was a significant differtence in the markedly effective rate between the two groups （P<0.05）. The improvement of the indexes in the treatment group was superior to the control group （P<0. 05 or P<0. 01）. Conclusion: The method for regulating and tonifying the kidney and removing blood stasis and toxic substances can improve clinical symptoms and signs

decrease blood Scr and urine protein. ET

TNF-α

increase Ccr

CGRP. relieve anemia state. regulate metabolic disturbance of lipids and Ca and P in the patient of chronic renal failure. It is an effective therapy for chronic renal failure.