Effects of Ganlan Jiejiu Yin on ALT and AST in Rats and Mice with Acute Alcoholic Hepatic Injury

Peng Bo

doi:10.13288/j.11-2166/r.2004.10.036

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Effects of Ganlan Jiejiu Yin on ALT and AST in Rats and Mice with Acute Alcoholic Hepatic Injury

更新时间：2021-11-22

- Effects of Ganlan Jiejiu Yin on ALT and AST in Rats and Mice with Acute Alcoholic Hepatic Injury
- Journal of Traditional Chinese Medicine Issue 10, Pages: 774-776(2004)
- 作者机构：
  
  河南中医学院肝病研究所河南省郑州市金水路1号,450008
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2004.10.036
  CLC： R285
- Published：2004
- 稿件说明：
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[1]彭勃.橄榄解酒饮对急性酒精性肝损伤大鼠、小鼠丙氨酸转氨酶、天冬氨酸转氨酶的影响[J].中医杂志,2004(10):774-776.

Peng Bo. Effects of Ganlan Jiejiu Yin on ALT and AST in Rats and Mice with Acute Alcoholic Hepatic Injury[J]. Journal of Traditional Chinese Medicine2004, (10): 774-776.
[1]彭勃.橄榄解酒饮对急性酒精性肝损伤大鼠、小鼠丙氨酸转氨酶、天冬氨酸转氨酶的影响[J].中医杂志,2004(10):774-776. DOI： 10.13288/j.11-2166/r.2004.10.036.

Peng Bo. Effects of Ganlan Jiejiu Yin on ALT and AST in Rats and Mice with Acute Alcoholic Hepatic Injury[J]. Journal of Traditional Chinese Medicine2004, (10): 774-776. DOI： 10.13288/j.11-2166/r.2004.10.036.

摘要

目的:观察橄榄解酒饮对大鼠、小鼠急性酒精性肝损伤的防治效果

初步探讨其对血清及肝匀浆丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）的影响。方法:采用白酒灌胃法造模

每天记录醉酒、醒酒时间

第3天检测血清ALT

第5天检测血清及肝匀浆ALT、AST

并与护肝胶囊对照。结果:橄榄解酒饮可显著降低大鼠、小鼠急性酒精性肝损伤模型醉酒率

提高醒/醉比;显著降低血清ALT、AST及肝匀浆ALT水平

与对照组比较差异有显著（P<0.05或P<0.01）。结论:橄榄解酒饮具有良好的防醉解酒护肝作用。

Abstract

Objective: To observe preventive and therapeutic effects of Ganlan Jiejiu Yin on acute alcoholic hepatic injury in the rat and the mouse

and to study preliminarily effects on alinine transaminase（ALT） and aspartic transaminase （AST） in serum and hepatic homogenate. Methods: The acute alcoholic hepatic injury model was made by stomach perfusion of white spirit for 5 days

and drunk time and the recovering time were observed every day

and serum ALT on the 3rd day and ALT and AST in serum and hepatic homogenate on the 5th day were determined

and the results were compared with those of Hugan Capsules. Results: Ganlan Jiejiu Yin could significantly decrease the drunk rate

increase the recovery/drunk ratio

and decrease ALT and AST in serum and ALT in hepatic homogenate with significant differences as compared with those of the control group. Conclusion: Ganlan Jiejiu Yin has good drunk-preventing

alcoholism-relieving and liver-protecting actions.

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