Clinical Observation on 31 Cases of Insomnia Treated by Chinese Drug Jieyu Pills

Hong Yongbo~1; Luo Hechun~2. Yao Weihai~1. et al.

doi:10.13288/j.11-2166/r.2004.11.028

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Clinical Observation on 31 Cases of Insomnia Treated by Chinese Drug Jieyu Pills

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- Clinical Observation on 31 Cases of Insomnia Treated by Chinese Drug Jieyu Pills
- Journal of Traditional Chinese Medicine Issue 11, Pages: 843-845(2004)
- 作者机构：
  
  1. 北京中医医院针灸科
  2. 北京大学精神卫生研究所
  3. 北京中医院针灸科
  4. 北京市崇文区体育馆路医院精神科
  5. 中国人民解放军第二六一医院精神科
  6. 中国中医研究院广安门医院北京市东城区美术馆后街23号,100010
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2004.11.028
  CLC： R256.23
- Published：2004
- 稿件说明：
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[1]洪永波,罗和春,姚卫海,王志强,梅桂森,曾丽萍,蒋学柱,赵志付.中药解郁丸治疗失眠31例临床观察[J].中医杂志,2004(11):843-845.

Hong Yongbo~1, Luo Hechun~2. Yao Weihai~1. et al.. Clinical Observation on 31 Cases of Insomnia Treated by Chinese Drug Jieyu Pills[J]. Journal of Traditional Chinese Medicine2004, (11): 843-845.
[1]洪永波,罗和春,姚卫海,王志强,梅桂森,曾丽萍,蒋学柱,赵志付.中药解郁丸治疗失眠31例临床观察[J].中医杂志,2004(11):843-845. DOI： 10.13288/j.11-2166/r.2004.11.028.

Hong Yongbo~1, Luo Hechun~2. Yao Weihai~1. et al.. Clinical Observation on 31 Cases of Insomnia Treated by Chinese Drug Jieyu Pills[J]. Journal of Traditional Chinese Medicine2004, (11): 843-845. DOI： 10.13288/j.11-2166/r.2004.11.028.

摘要

目的:验证解郁丸治疗失眠的临床疗效、不良反应及安全性。方法:通过随机对照试验

将53例患者分为中药组31例.对照组22例

于用药前及用药后第11天、28天分别采用睡眠状态问卷量表（SQ）、抑郁自评量表（SDS）、焦虑自评量表（SAS）评定药物疗效

采用临床总体印象量表（CGI）中对疗效和副反应的评分法评定不良反应和疗效指数。结果:中药组显效率（54.9%）与对照组（59.1%）相当（P>0.05）:中药组与对照组治疗后SQ、SDS和SAS分数均明显低于治疗前（P<0.01）

两组间比较差异无显著性（P>0.05）。治疗后中药组的副反应分数明显低于对照组（P<0.01）

中药组疗效指数显著高于对照组（P<0.01）。结论:解郁丸治疗失眠疗效与曲唑酮相当

不良反应明显少于曲唑酮。

Abstract

Objective: To invesigate the clinical thertapeutic effect

adverse effects and safety of Jieyu Pills in treatment of insomnia. Methods: 53 cases of insomnia were randomly divided into treatment group （n=31） treated by Jieyu Fills and control group （n= 22）treated by Trazodone. The therapeutic effects were assessed before administration and at the 14th and 28th days after administration with Sleeping Questionnaire （SQ）

Self-Rating Depression Scale （SDS）and Self-Rating Anxiety Scale（SAS）

and the adverse effect and the efficacy index were evaluated by the method in the scale of Clinical Global Impression （CGI）. Results: The marked improvement rate was 54. 9%. in the treatment group and 59. 1% in the control group. with no significant difference between the two groups （P>0. 05）. After treatment

the scores for SQ

SIXS and SAS decreased significantly as compared with those before treatment （P<0. 01 ）with no significant difference between the two groups （P>0. 05）. and the score in the treatment group was lower than that in the control group （P<0. 01） and the efficacy index in the treatment group was higher than that in the control group （P<0. 01）. Conclusion: Jieyu Pills and Trazodone have similar therapeutic effect on insomnia. but Jieyu Pills have less adverse effects.

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