Effects of Qixue Bingzhi Prescription on Hypersensitive C-reactive Protein and Other Indexes in the Patient of Cervical Atherosclerosis

Zhang Hongxia; Liu Jiangang; Shi Dazhuo

doi:10.13288/j.11-2166/r.2004.12.015

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Effects of Qixue Bingzhi Prescription on Hypersensitive C-reactive Protein and Other Indexes in the Patient of Cervical Atherosclerosis

更新时间：2021-11-20

- Effects of Qixue Bingzhi Prescription on Hypersensitive C-reactive Protein and Other Indexes in the Patient of Cervical Atherosclerosis
- Journal of Traditional Chinese Medicine Issue 12, Pages: 907-910(2004)
- 作者机构：
  
  1. 中国中医研究院西苑医院心血管科
  2. 中国中医研究院西苑医院心血管科北京市海淀区西苑操场1号,100091
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2004.12.015
  CLC： R259
- Published：2004
- 稿件说明：
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[1]张红霞,刘剑刚,史大卓.气血并治方对颈动脉粥样硬化患者超敏C反应蛋白等指标的影响[J].中医杂志,2004(12):907-910.

Zhang Hongxia, Liu Jiangang, Shi Dazhuo. Effects of Qixue Bingzhi Prescription on Hypersensitive C-reactive Protein and Other Indexes in the Patient of Cervical Atherosclerosis[J]. Journal of Traditional Chinese Medicine2004, (12): 907-910.
[1]张红霞,刘剑刚,史大卓.气血并治方对颈动脉粥样硬化患者超敏C反应蛋白等指标的影响[J].中医杂志,2004(12):907-910. DOI： 10.13288/j.11-2166/r.2004.12.015.

Zhang Hongxia, Liu Jiangang, Shi Dazhuo. Effects of Qixue Bingzhi Prescription on Hypersensitive C-reactive Protein and Other Indexes in the Patient of Cervical Atherosclerosis[J]. Journal of Traditional Chinese Medicine2004, (12): 907-910. DOI： 10.13288/j.11-2166/r.2004.12.015.

摘要

目的:探讨气血并治方对颈动脉粥样硬化（AS）患者的干预作用。方法:63例颈AS患者

随机单盲分为治疗组（33例）和对照组（30例）。另设相同年龄段健康组25例。对照组给予西药基础治疗

治疗组在此基础上加气血并治方。疗程1个月

观察患者血脂代谢、白细胞介素水平、超敏C反应蛋白（Hs-CRP）含量和白细胞粘附表达率的变化。结果:治疗组对总胆固醇（TC）、甘油三酯（TG）、AS指数（TC/HDL-C）、白细胞介素6（IL-6）、白细胞介素8（IL-8）、Hs-CRP水平以及淋巴细胞和中性粒细胞粘附分子表达率（1CD11b和zCD11b）有显著降低作用（P<0.05）;与对照组治疗后比较

治疗组明显降低TC/HLD-C

且对IL-6、Hs-CRP和1CD11b的影响更为明显（P<0.05）。安全性指标治疗前后均无明显改变（P>0.05）;结论:气血并治方可有效、安全干预颈AS患者的血脂代谢和炎症反应

在预防AS形成、稳定斑块方面具有发展前景。

Abstract

Objective:To study intervenient action of Qixue Bingzhi Prescription on the patient of cervical atherosclerosis（AS）. Methods:63 cases of cervical AS were randomly divided into a treatment group（n=33） and a control group（n=30）

with 25 cases of same age ranges used as healthy group. The control group was treated with basic treatment of western medicine and the treatment group with the basic treatment plus Qixue Bingzhi Prescription for one month. Changes of blood lipid metabolism

interleukin levels

supersensitive C-reactive protein（Hs-CRP） content and the leukocyte adherence expression rate were observed. Results: The total cholesterol （TC）

triglyceride（TG）

AS index （TC/HDL-C）

interleukin-6 （IL-6）

interleukin-8 （IL-8） and Hs-CRP levels and lymphocytes and the neutrophilic granulocyte adhesion molecule expression rate （ICD11b and zCD11b） decreased significantly（P <0. 05） in the treatment group

with significant decrease of TC/HDL-C and more significant effects on IL-6

Hs-CRP and ICD11b as compared with the control group after treatment. The indexes of safety before and after treatment did not have significant changes （P>0. 05）

Conclusion: Qixue Bingzhi Prescription can effectively and safely intervene in blood lipid metabolism and inflammatory reaction in the patient of cervical AS

and it has prospect of development in preventing formation of AS and stabilizing plaque.

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