Study on Correlativity of TCM Syndrome Types with Expression of c-fos and Other Genes in Leukocytes in the Patient of Hypertension and Type Ⅱ Diabetes with Blood Stasis

Ma Min

doi:10.13288/j.11-2166/r.2004.12.029

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Study on Correlativity of TCM Syndrome Types with Expression of c-fos and Other Genes in Leukocytes in the Patient of Hypertension and Type Ⅱ Diabetes with Blood Stasis

更新时间：2021-11-20

- Study on Correlativity of TCM Syndrome Types with Expression of c-fos and Other Genes in Leukocytes in the Patient of Hypertension and Type Ⅱ Diabetes with Blood Stasis
- Journal of Traditional Chinese Medicine Issue 12, Pages: 930-933(2004)
- 作者机构：
  
  暨南大学医学院中医系广东省广州市石牌,510632
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2004.12.029
  CLC： R259
- Published：2004
- 稿件说明：
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[1]马民.高血压病和2型糖尿病血瘀证患者辨证分型与白细胞中c-fos等基因表达的相关性研究[J].中医杂志,2004(12):930-933.

Ma Min. Study on Correlativity of TCM Syndrome Types with Expression of c-fos and Other Genes in Leukocytes in the Patient of Hypertension and Type Ⅱ Diabetes with Blood Stasis[J]. Journal of Traditional Chinese Medicine2004, (12): 930-933.
[1]马民.高血压病和2型糖尿病血瘀证患者辨证分型与白细胞中c-fos等基因表达的相关性研究[J].中医杂志,2004(12):930-933. DOI： 10.13288/j.11-2166/r.2004.12.029.

Ma Min. Study on Correlativity of TCM Syndrome Types with Expression of c-fos and Other Genes in Leukocytes in the Patient of Hypertension and Type Ⅱ Diabetes with Blood Stasis[J]. Journal of Traditional Chinese Medicine2004, (12): 930-933. DOI： 10.13288/j.11-2166/r.2004.12.029.

摘要

目的:进一步探索血瘀证的微观机理

从基因水平探讨血瘀证微观实质。方法:以病证结合方式

严格按照诊断标准选取160例高血压病和2型糖尿病血瘀证和非血瘀证患者

用先进的血液生化指标和实验技术

进行了c-fos基因、c-jun基因和CD62p基因表达的观察、对比、分析

并以健康人为对照

从基因水平对血瘀证形成的微观机理和演变规律进行探索。结果:通过对血瘀证密切相关的微观指标的观察和分析

提出了血瘀证患者存在c-fos、c-jun、CD62p基因异常表达

并且其指标的异常及基因表达水平的高低与血瘀证各型之间存在密切关系。结论:基因组学是血瘀证实质研究的最佳切入点。血瘀证现代研究应积极引进微观辨证学和基因科学的最新成果

以丰富和发展中医基础理论

并为中医临床治疗学提供分子生物学依据。

Abstract

Objective: To further probe into mechanism and essence of blood stasis from gene level. Methods: 160 cases of hypertension and type Ⅱ diabetes with blood stasis or no blood stasis were strictly selected according to criteria of diagnosis and by combination of diseases with syndrome

and expressions of c-fos

c-jun and CD62p genes were investigated

compared and analyzed with healthy persons as controls. Results: There were abnormal expressions of c-fos

c-jun and CD62p genes in the patient with blood stasis

and there were close relation of the abnormality and expression levels of the genes with various types of blood stasis. Conclusion: Genomics is the best way for studies of essence of blood stasis syndrome

which can enrich and develop basic theory of TCM and provide a basis of molecular biology for clinical therapeutics of TCM.

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