Effect of Yangxin Tongmai Tablet on Apoptosis of Pathological Cells in the Rat of Atherosclerosis with Phlegm Stasis

Wang Dongsheng~1; Yuan Zhaokai~2; Huang Xianping~2; et al.

doi:10.13288/j.11-2166/r.2004.12.031

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Effect of Yangxin Tongmai Tablet on Apoptosis of Pathological Cells in the Rat of Atherosclerosis with Phlegm Stasis

更新时间：2021-11-20

- Effect of Yangxin Tongmai Tablet on Apoptosis of Pathological Cells in the Rat of Atherosclerosis with Phlegm Stasis
- Journal of Traditional Chinese Medicine Issue 12, Pages: 937-940(2004)
- 作者机构：
  
  1. 中南大学湘雅医院血液科
  2. 湖南中医学院中医诊断研究所
  3. 中南大学湘雅医院血液科长沙市湘雅路141号,410008
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2004.12.031
  CLC： R285
- Published：2004
- 稿件说明：
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[1]王东生,袁肇凯,黄献平,卢芳国,谢梦洲,郭志华,谭光波,毛以林,陈方平.养心通脉片对动脉粥样硬化大鼠“痰瘀”病理细胞凋亡的影响[J].中医杂志,2004(12):937-940.

Wang Dongsheng~1, Yuan Zhaokai~2, Huang Xianping~2, et al. Effect of Yangxin Tongmai Tablet on Apoptosis of Pathological Cells in the Rat of Atherosclerosis with Phlegm Stasis[J]. Journal of Traditional Chinese Medicine2004, (12): 937-940.
[1]王东生,袁肇凯,黄献平,卢芳国,谢梦洲,郭志华,谭光波,毛以林,陈方平.养心通脉片对动脉粥样硬化大鼠“痰瘀”病理细胞凋亡的影响[J].中医杂志,2004(12):937-940. DOI： 10.13288/j.11-2166/r.2004.12.031.

Wang Dongsheng~1, Yuan Zhaokai~2, Huang Xianping~2, et al. Effect of Yangxin Tongmai Tablet on Apoptosis of Pathological Cells in the Rat of Atherosclerosis with Phlegm Stasis[J]. Journal of Traditional Chinese Medicine2004, (12): 937-940. DOI： 10.13288/j.11-2166/r.2004.12.031.

摘要

目的:观察养心通脉片对动脉粥样硬化（AS）大鼠“痰瘀”病理细胞凋亡的影响。方法:采用高脂饲料喂饲法复制Wistar大鼠动脉粥样硬化模型

造模1个月后检测动脉斑块形成

作为模型成功的指标

治疗组用养心通脉片

对照组用绞股蓝总甙片治疗1个月。检测血脂、血糖、血液流变学、胰岛素

光镜、电镜及运用免疫组化法观察动脉血管平滑肌细胞（VSMC）细胞凋亡的变化。结果:养心通脉片对动脉粥样硬化模型大鼠有明显的降脂、改善血液流变性、改善胰岛素抵抗功能

能消退斑块并维持主动脉组织结构及功能

使细胞凋亡趋于正常。结论:养心通脉片对改善AS大鼠“痰瘀”病理细胞凋亡有良好的效果。

Abstract

Objective: To observe the effect of Yangxin Tongmai Tablet on apoptosis of pathological cells in the rat of atherosclerosis （AS） with phlegm stasis. Methods: Atherosclerosis rat model was developed by high fat gorage. Formation of arterial plaques was detected one month after modeling as index of successful modeling. The treatment group was treated by Yangxin Tongmai Tablet and the control group with Jiao Gu Lan Zhong Dai Tablet for one month and then changes of blood lipid

blood sugar

hemorheological indexes

insulin

apoptosis of arterial vascular smooth muscular cells（VSMC） were observed. Results: Yangxin Tongmai Tablet could significantly decrease blood lipid

improve hemorheological indexes and insulin resistance

remove plagues and maintain structures and functions of the aorta

and make apoptosis tend to normal. Conclusion: Yangxin Tongmai Tablet has a good effect in improving apoptosis of pathological cells in the rat of AS with phlegm stasis.

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