Effects of Recipes for Tonifying and Supplementing on Apoptosis of Splenocytes in Mice of Injected by Cyclophosphamide

Xu Dongqing Wang Mingyan Zhao Fengming

doi:10.13288/j.11-2166/r.2005.02.028

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Effects of Recipes for Tonifying and Supplementing on Apoptosis of Splenocytes in Mice of Injected by Cyclophosphamide

更新时间：2021-11-20

- Effects of Recipes for Tonifying and Supplementing on Apoptosis of Splenocytes in Mice of Injected by Cyclophosphamide
- Journal of Traditional Chinese Medicine Issue 2, Pages: 134-135(2005)
- 作者机构：
  
  1. 南京中医药大学基础医学院微生物免疫教研室
  2. 南京中医药大学基础医学院微生物免疫教研室南京市汉中路282号,210029
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2005.02.028
  CLC： R285.5
- Published：2005
- 稿件说明：
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[1]许冬青,王明艳,赵凤鸣,姜海英,詹臻.补益方抗环磷酰胺造模小鼠脾细胞凋亡作用的研究[J].中医杂志,2005(02):134-135.

Xu Dongqing Wang Mingyan Zhao Fengming. Effects of Recipes for Tonifying and Supplementing on Apoptosis of Splenocytes in Mice of Injected by Cyclophosphamide[J]. Journal of Traditional Chinese Medicine2005, (2): 134-135.
[1]许冬青,王明艳,赵凤鸣,姜海英,詹臻.补益方抗环磷酰胺造模小鼠脾细胞凋亡作用的研究[J].中医杂志,2005(02):134-135. DOI： 10.13288/j.11-2166/r.2005.02.028.

Xu Dongqing Wang Mingyan Zhao Fengming. Effects of Recipes for Tonifying and Supplementing on Apoptosis of Splenocytes in Mice of Injected by Cyclophosphamide[J]. Journal of Traditional Chinese Medicine2005, (2): 134-135. DOI： 10.13288/j.11-2166/r.2005.02.028.

摘要

目的:研究六味地黄丸等5种补益方对环磷酰胺（CPP）造模小鼠脾细胞凋亡及细胞周期的影响方法:选择 ICR 小鼠

采用流式细胞术检测脾细胞凋亡率及细胞周期等。结果:5种补益方中

四君子汤、六味地黄丸、生脉散、金匮肾气丸能拮抗CPP 引起的脾细胞增殖抑制;六味地黄丸、四君子汤能拮抗 CPP 引起的脾细胞凋亡;5种补益方均能拮抗 CPP 所致的脾脏萎缩。结论:5种补益方均有不同程度的改善 CPP 所致脾脏损害的作用

其中以四君子汤、六味地黄丸效果较佳。

Abstract

Objective:To study effects of 5 recipes for tonifing and supplementing on apoptosis and splenocytes in mice treated with cyclophosphamide.Methods:Apoptosis and cellular cycles of splenocytes were detected by flowcytometric analysis.Results:Sijunzi Decoction

Liuwei Dihuang Pill

Shengmai Powder

Jingui Shenqi Pill could antagonize the decline of proliferation induced by cyclophosphamide

and Sijunzi Decoction and Liuwei Dihuang Pill could resist the apoptosis of splenocytes caused by cyclophosphamide;and the recipes all could inhibit atrophy of the spleen induced by cyclophosphamide Conclusion:The 5 recipes for tonifying and supplementing all can improve the injury of the spleen induced by cyclopbosphamide in varying degrees

Sijunzi Decoction and Liuwei Dihuang Pill being the best.

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