Objective:To observe effect of Xiaoyu Zhixue Tablets on expression of platelet membrane glucoprotein in the patient of hemorrhagic thrombopathy and probe into the mechanism of the therapy.Methods:148 cases of hemorrhagic thrombopathy were randomly divided into a Chinese drug group（n=98）treated by Xiaoyu Zhixue Tablets

and a Western medicine group（n=50） treated by adrenosem

vitamine C

K

P.They were treated for 6 months.After treatment the therapeutic effect of hemostasis and the recovery rate of platelet aggregation in the two group were observed and analyzed.Before and after treatment expressions of platelet membrane glucoproteins GP Ⅰ b/Ⅸ

GP Ⅱ b/Ⅲa

GP Ⅰ b

GP Ⅱ b

GP Ⅲ a and p-selectin expression were detected with flow cytometry in the two groups and in 34 healthy persons（normal group）.Results:The total effecive rate of hemostasis was 89. 8% in the Chinese drug group and 54.0% in the Western medicine group

and the recovery rate of platelet aggegation was 72.4% in the Chinese drug group and 4.0% in the Western medicine group

with significant differences（both P<0.01）.Before treatment

GP Ⅰ b/Ⅸ

GP Ⅱ b/Ⅲ a

GP Ⅰ b

GP Ⅲ a and p-selectin expression’s fluorescent intensities in the patients of the two groups were lower than those in the healthy persons（P<0.05）

and after treatment with Chinese drug

the platelet membrane glucoprotein expression significantly increased and was higher than that in the Western medicine group（P<0.05）

but with no significant difference as compared with the normal group（P>0.05）.Conclusion:Xiaoyu Zhixue Tablets can up-regulate platelet membrane glucoproteins GP Ⅰ b/Ⅸ

GP Ⅱ b/Ⅲ a

GP Ⅰ b

GP Ⅲ a and p-selectin expression

which is possibly one of the mechanisms for treatment of hemorrhagic thrombopathy.