Effects of Modified Yupingfeng Powder on Cellular Immune Function in Mice of Wound Stress

doi:10.13288/j.11-2166/r.2005.05.029

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Effects of Modified Yupingfeng Powder on Cellular Immune Function in Mice of Wound Stress

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- Effects of Modified Yupingfeng Powder on Cellular Immune Function in Mice of Wound Stress
- Journal of Traditional Chinese Medicine Issue 5, Pages: 380-382(2005)
- 作者机构：
  
  1. 中国人民解放军第四五七医院病理科
  2. 美国国家卫生研究院
  3. 湖北中医学院
  4. 华中科技大学同济医学院免疫学系湖北省武汉市工农兵路15号,430012
  5. 研究生
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2005.05.029
  CLC： R285.5
- Published：2005
- 稿件说明：
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[1]曾广仙,陈新,刘俊英,衷学军,代丽红,赵璐,沈关心.加味玉屏风散对创伤应激小鼠细胞免疫功能的影响[J].中医杂志,2005(05):380-382.

Effects of Modified Yupingfeng Powder on Cellular Immune Function in Mice of Wound Stress[J]. Journal of Traditional Chinese Medicine2005, (5): 380-382.
[1]曾广仙,陈新,刘俊英,衷学军,代丽红,赵璐,沈关心.加味玉屏风散对创伤应激小鼠细胞免疫功能的影响[J].中医杂志,2005(05):380-382. DOI： 10.13288/j.11-2166/r.2005.05.029.

Effects of Modified Yupingfeng Powder on Cellular Immune Function in Mice of Wound Stress[J]. Journal of Traditional Chinese Medicine2005, (5): 380-382. DOI： 10.13288/j.11-2166/r.2005.05.029.

摘要

目的:探讨加味玉屏风散对创伤应激小鼠细胞免疫功能的影响。方法:采用小鼠截肢应激模型

检测创伤后小鼠细胞免疫功能变此。结果:创伤后小鼠细胞免疫功能受抑

包括γ-干扰素（INF-γ）水平、CD

水平、CD

/CD

比值降低;转化生长因子-β（TGF-β）水平升高;核转录因子-κBmRNA（NF-κBmRNA）、白细胞介素10-BmRNA（IL-10mRNA）表达增加;高、中、低三种浓度加味玉屏风散对上述指标的变化具有不同程度的纠正作用

其中高剂量组小鼠各项指标均恢复正常。结论:创伤后小鼠细胞免疫功能受抑;加味玉屏风散可有效恢复其细胞免疫功能。

Abstract

Objective:To observe effects of modified Yupingfeng Powder on cellular immune function in mice of wound stress.Methods: Changes of cellular immune function were detected in mice of amputation stress.Results:In the mice after wound

cellular immune function including γ-interferon（IFN-γ）

level

/CD

ratio decreased

transforming growth factor-β（TGF-β）level and nuclear transcript factor（NF-kB）mRNA and interleukin-10（IL-10）mRNA expression increased;Modified Yupingfeng Powder of high

middle and low dosages could correct the above indexes in varying degrees

and the various indexes in the mice of the high dosage group all restored to normal.Conclusion:After wound

cellular immune function of the mice was inhibited

and modified Yupingfeng Powder can effectively restore cellular immune function.

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