Effects of Fuzheng Huoxue Recipe on Expression of Fn and TGF-β1 mRNA in the Renal Tissue of the Rat with 5/6 Nephrectomy[J]. Journal of Traditional Chinese Medicine2005, (6): 454-457.
Effects of Fuzheng Huoxue Recipe on Expression of Fn and TGF-β1 mRNA in the Renal Tissue of the Rat with 5/6 Nephrectomy[J]. Journal of Traditional Chinese Medicine2005, (6): 454-457.DOI: 10.13288/j.11-2166/r.2005.06.036.
Effects of Fuzheng Huoxue Recipe on Expression of Fn and TGF-β1 mRNA in the Renal Tissue of the Rat with 5/6 Nephrectomy
Objective:To probe effects of Fuzheng Huoxue Recipe on expression of fibronectin(Fn)and transforming growth factor-β1 mRNA (TGF-β1 mRNA)in the renal tissue of the rat with chronic renal failure(CRF).Methods:CRF rat model was established by 5/6 nephreetomy
and then they were randomly divided into model group
Fuzheng Huoxue Decoction group
Huangqi group
Danshen group and Enalapril group
with a normal control group.After treatment of 2 months
expression of Fn and TGF-β1 mRNA in the renal tissue of the rat with CRF were observed.Results:Blood creatinine(SCr)
urea nitrogen(BUN)
24-hour protein in urine and expression of Fn and TGF-β1 mRNA in the renal tissue in the model group were significantly higher than those in the normal control group.After treatment with Fuzheng Huoxue Recipe
expression of Fn and TGF-β1 mRNA in the renal tissue and protein level in urine decreased significantly.Conclusion:Fuzheng Huoxue Recipe can improve renal function of the rat with CRF
and delay development of CRF
which are possibly related with the decrease of expression of Fn and TGF-β1 mRNA in the renal tissue of the rat with CRF.
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Related Author
Li Jun1
He Liqun2
Li Yi2
Zhu Pijiang~1
Wei Xianjin~2
Zhou Xun~1
et al.
刘永平
Related Institution
The Fifth Affiliated Hospital of Zunyi Medical College
Shuguang Hospital Affiliated to Shanghai University of TCM
Institute of Integrated Chinese and Western Medicine for Treatment of Renal Diseases,Zhenjiang City