Clinical and Experimental Study on Weiling Granule for Treatment of Peptic Ulcer

Lin Hexi Wang Yishan Zhu Guoshu

doi:10.13288/j.11-2166/r.2005.08.022

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Clinical and Experimental Study on Weiling Granule for Treatment of Peptic Ulcer

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- Clinical and Experimental Study on Weiling Granule for Treatment of Peptic Ulcer
- Journal of Traditional Chinese Medicine Issue 8, Pages: 590-592(2005)
- 作者机构：
  
  1. 福建省泉州市中医院
  2. 福建中医学院附属第二医院
  3. 福建省新药药理研究基地泉州市温陵南路215号,362000
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2005.08.022
  CLC： R259
- Published：2005
- 稿件说明：
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[1]林禾禧,王奕珊,朱国曙,张闽光,林振川,陈奕昭,何成龙,吕方,杨春波,谢振家.胃灵颗粒治疗消化性溃疡的临床与实验研究[J].中医杂志,2005(08):590-592.

Lin Hexi Wang Yishan Zhu Guoshu. Clinical and Experimental Study on Weiling Granule for Treatment of Peptic Ulcer[J]. Journal of Traditional Chinese Medicine2005, (8): 590-592.
[1]林禾禧,王奕珊,朱国曙,张闽光,林振川,陈奕昭,何成龙,吕方,杨春波,谢振家.胃灵颗粒治疗消化性溃疡的临床与实验研究[J].中医杂志,2005(08):590-592. DOI： 10.13288/j.11-2166/r.2005.08.022.

Lin Hexi Wang Yishan Zhu Guoshu. Clinical and Experimental Study on Weiling Granule for Treatment of Peptic Ulcer[J]. Journal of Traditional Chinese Medicine2005, (8): 590-592. DOI： 10.13288/j.11-2166/r.2005.08.022.

摘要

目的:研究胃灵颗粒对消化性溃疡愈合质量（QOUH）和大鼠乙酸慢性胃溃疡愈合质量的影响。方法:用随机分组的方法

观察临床消化性溃疡的复发率并用苏木精伊红染色对大鼠愈合性胃溃疡再生黏膜进行定量观察

测定胃壁结合黏液量、胃酸、胃蛋白酶活性。结果:胃灵颗粒组能降低消化性溃疡的复发率

改善胃溃疡大鼠胃黏膜的组织损伤并提高胃壁结合黏液量

减少胃酸的排出。结论:胃灵颗粒能提高 QOUH

是临床抗消化性溃疡复发的可能机制之一。

Abstract

Objective:To study on effects of Welling Granule on union of peptic ulcer and the gastrical ulcer induced by acetic acid in the rat. Methods:With random grouping method

the clinical recurrence rate of peptic ulcer

and regenerated macosa of healing gastric ulcer in the rat was investigated quantitatively with hematoxylin-eosin staining

and gastric wall combining macus amount

gastric acid and pepsin activity were determined.Results:Weiling Granule could decrease the recurrence rate of peptic ulcer

improve injury of the tissue of gastric macosa in the rat

increase gastric wall combining mucus amount

and decrease secretion of gastric acid.Conclusion:Weiling Granule can increase quality of ulcerative healing

which is possibly one of the mechanisms of anti- recurrence of peptic ulcer clinically.

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