Experimental Study on Intervene Action of Huashi Recipe on Non-Enzymic Glycation and Oxidation in the Renal Tissue of Diabetic Rats

doi:10.13288/j.11-2166/r.2005.08.038

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Experimental Study on Intervene Action of Huashi Recipe on Non-Enzymic Glycation and Oxidation in the Renal Tissue of Diabetic Rats

更新时间：2021-11-20

- Experimental Study on Intervene Action of Huashi Recipe on Non-Enzymic Glycation and Oxidation in the Renal Tissue of Diabetic Rats
- Journal of Traditional Chinese Medicine Issue 8, Pages: 619-621(2005)
- 作者机构：
  
  1. 天津市中医学院第一附属医院内分泌科
  2. 天津中医学院基础医学部
  3. 天津中医学院第一附属医院内分泌科
  4. 天津中医学院基础医学部天津市南开区鞍山西道314号,300193
  5. 天津市南开鞍山西道314号,300193
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2005.08.038
  CLC： R285.5
- Published：2005
- 稿件说明：
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[1]梁苹茂,张国霞,朱小棣,董承超,吴深涛,郑开梅.化湿方对糖尿病大鼠肾组织非酶糖化及氧化干预作用的实验研究[J].中医杂志,2005(08):619-621.

Experimental Study on Intervene Action of Huashi Recipe on Non-Enzymic Glycation and Oxidation in the Renal Tissue of Diabetic Rats[J]. Journal of Traditional Chinese Medicine2005, (8): 619-621.
[1]梁苹茂,张国霞,朱小棣,董承超,吴深涛,郑开梅.化湿方对糖尿病大鼠肾组织非酶糖化及氧化干预作用的实验研究[J].中医杂志,2005(08):619-621. DOI： 10.13288/j.11-2166/r.2005.08.038.

Experimental Study on Intervene Action of Huashi Recipe on Non-Enzymic Glycation and Oxidation in the Renal Tissue of Diabetic Rats[J]. Journal of Traditional Chinese Medicine2005, (8): 619-621. DOI： 10.13288/j.11-2166/r.2005.08.038.

摘要

目的:研究化湿方治疗糖尿病肾病的可能机制。方法:分别用化湿方、氨基胍处理糖尿病大鼠

12周后测肾皮质晚期糖化终产物（AGEs）、丙二醛（MDA）、超氧化物歧化酶（SOD）、尿白蛋白排泄率、血肌酐（SCr）、尿素氮（BUN）

观察肾组织形态。结果:化湿方能减少糖尿病大鼠肾皮质 AGEs 表达

提高 SOD 活性、降低 MDA 含量

减少尿白蛋白排泄率

改善肾功能

改善肾组织形态。结论:化湿方是较理想的中药非酶糖化抑制剂并具有抑制氧化应激反应的功能

其作用不依赖于降低血糖。

Abstract

Objective:To study on the mechanism of Huashi Recipe for treatment of diabetic nephrosis.Methods:The diabetic rats were treated by Huashi Recipe and aminoguanidine respectively

and 12 weeks later

advanced glycation endproducts（AGEs）in the renal cortex and MDA

SOD in the renal tissue

excretion rate of urinary albumin

blood creatinine（Scr）and urea nitrogen levels were determined and form of the renal tissue was observed.Results:Huashi Recipe could decrease expression of AGEs in the renal cortex

increase SOD activity

reduce MDA content and excretion rate of urinary albumin

improve renal function and form of the renal tissue.Conclusion:Huashi Recipe is a more ideal TCM non-enzyme glycation inhibitor with the function of inhibiting oxidation stress response

whicb does not depend on decrease of blood glucose.

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