Objective:To observe therapeutic effects of Plendil and Lotensin on hypertension of different TCM syndrome types

and select antihypertensives based on TCM syndrome differentiation.Methods:Hypertension was diagnosed and graded according to criteria of WHO and was divided into 4 types based on The Guiding Principles of Clinical Studies of New TCM.216 cases of hypertension were randomly divided into 2 groups and they were treated respectively with Plendil and Lotensin for 4 weeks.Their effects on blood pressure and the blood pressure of different syndrome types were analyzed and the therapeutic effects on different symptoms were observed.Results:The two drugs were basically same in decreasing the amplitude of blood pressure of the patients

but had obvious differences in extent of blood pressure reduciton for the patients of the 4 TCM syndrome types.Lotensin could obviously decrease blood pressure for the patient of liver-fire hyperactivity type

and Plendil could better decrease blood pressure for the patient of accumulation of phlegm-dampness than other 3 types.There was no significant difference between the type of Yang- hyperactivity due to Yin-deficiency and the type of both Yin-and Yang-deficiency.And the similar results were attained in the improving actions on symptoms of various syndrome types.Conclusion:The Antihypertensives have different therapeutic effects on hypertension of different TCM syndrome types

indicating that western medicine have some characteristics of Chinese medicinal herbs

and antihypertensives can be selected based on TCM syndrome differentiation.