Experimental Study on Quyu Xiaoban Capsule for Removing Atherosclerosis[J]. Journal of Traditional Chinese Medicine2005, (10): 777-779.DOI: 10.13288/j.11-2166/r.2005.10.029.
Experimental Study on Quyu Xiaoban Capsule for Removing Atherosclerosis
腹主动脉超声图像平均回声强度的校正值(AIIc%)较造模后测量值显著增大(P<0.01)。造模后、自然消退组和中药组形态学检查有明显差异。结论:祛瘀消斑胶囊具有消退实验兔 AS 的作用
高频超声技术可作为定性和定量随访 AS 动态变化的可靠方法。
Abstract
Objective:To observe the action of Quyu Xiaoban Capsule in removing atherosclerosis(AS)with high frequency ultrasonography. Methods:20 rabbits were fed with forage of high cholesterol
and at the end of the 12th week
16 model rabbits were randomly divided into a natural removing group(control group)and a Chinese drug group
8 in each group.Blood lipids determination and high frequency uhrasonography were carried out and the outcomes were compared with the results of pathological examination at the beginning
the end of the 12th week and the end of the 24th week.Results:12 weeks after modeling
blood total cholesterol (TC)
triglyceride(TG)and lower density lipoprotein-cholesterol(LDL-C)in the model rabbit increased significantly and intima- media thiekness(IMT)thickened significantly(P<0.05 or P<0.01).At the end of the 24th week
all indexes of blood lipids in both groups decreased significantly
and TC
TG and LDL-C in the Chinese drug group were significantly lower than those in the control group
and IMT was significantly smaller than that in the control group(P<0.05).The corrective walue of the mean intensity of the ultrasonngram of the abdominal aorta(AIIc%)in the model rabbit increased significantly(P<0.01)
and no significant difference between the two groups in morphological examinations was found.Conclusion:Quyu Xiaoban Capsule has the function of removing AS
and high frequency ultrasonography is a reliable method for qualitatively and quantitatively following-up dynamic changes of AS.