Effects of Weikang Capsule on Blood Nitric Oxide and Endothin-1 Contents in 120 Cases of Peptic Ulcer

doi:10.13288/j.11-2166/r.2005.11.014

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Effects of Weikang Capsule on Blood Nitric Oxide and Endothin-1 Contents in 120 Cases of Peptic Ulcer

更新时间：2021-11-20

- Effects of Weikang Capsule on Blood Nitric Oxide and Endothin-1 Contents in 120 Cases of Peptic Ulcer
- Journal of Traditional Chinese Medicine Issue 11, Pages: 822-823(2005)
- 作者机构：
  
  1. 天津市中医药研究院附属医院脾胃科
  2. 内蒙古自治区林业总医院
  3. 内蒙古自治区林业总医院天津市和平区多伦道79号,300020
  4. 天津市中医药研究院附属医院脾胃科内蒙古自治区林业总医院内蒙古自治区林业总医院天津市和平区多伦道79号,300020
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2005.11.014
  CLC： R259
- Published：2005
- 稿件说明：
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[1]韩秋艳,韩秋鑫,郭斌.胃康胶囊对120例消化性溃疡患者血液一氧化氮及内皮素-1变化的影响[J].中医杂志,2005(11):822-823.

Effects of Weikang Capsule on Blood Nitric Oxide and Endothin-1 Contents in 120 Cases of Peptic Ulcer[J]. Journal of Traditional Chinese Medicine2005, (11): 822-823.
[1]韩秋艳,韩秋鑫,郭斌.胃康胶囊对120例消化性溃疡患者血液一氧化氮及内皮素-1变化的影响[J].中医杂志,2005(11):822-823. DOI： 10.13288/j.11-2166/r.2005.11.014.

Effects of Weikang Capsule on Blood Nitric Oxide and Endothin-1 Contents in 120 Cases of Peptic Ulcer[J]. Journal of Traditional Chinese Medicine2005, (11): 822-823. DOI： 10.13288/j.11-2166/r.2005.11.014.

摘要

目的:探讨胃康胶囊对消化性溃疡的疗效及其在一氧化氮（NO）及内皮素-1（ET-1）负反馈调节水平上的变化意义。方法:将本病患者随机分为治疗组和对照组

观察两组疗效并对治疗前后 NO-ET-1进行测定对比。结果:治疗组有效率（95%）明显高于对照组（77%）（P<0.01）。治疗组 NO 治疗前后差异有显著性（P<0.01）

而对照组差异虽具显著性（P<0.05）

但明显低于治疗组;两组 ET-1治疗前均明显高于健康对照组

治疗后均有所下降

但治疗组明显优于对照组（P<0.01）。结论:消化性溃疡患者的 NO-ET-1水平有所改变

胃康胶囊可能是通过 NO-ET-1负反馈调节环而起作用的。

Abstract

Objective:To probe into treatment of peptic ulcer with Weikang Capsule and observe its effect on blood nitric oxide（NO）and endothin-1（ET-1）.Methods:The patients were randomly divided into a Weikang Capsule treatment group and a Cimetidine control group.Their therapeutic effects

and level of NO and ET-1 before and after treatment were observed and compared. Results:The effective rate（95%）in the treatment group was significantly higher than 77% in the control group（P<0.01）. There was significant difference before and after treatment in the treatment group （P<0.01）and in the control group（P<0. 05）

but the treatment group was significantly higher than the control group;the ET-1 level before treatment in both groups was significantly higher than that in the health control group and decreased after treatment

but the treatment group was significantly superior to the control group（P<0.01）.Conclusion:level of NO and ET-1 in the patient of peptic ulcer shows changes

and Weikang Capsule cures peptic ulcer possibly through NO-ET-1 negative feedback regulation.

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