Effects of Huatan Huoxue Prescription on Expressions of Peroxisome Proliferation Substance Activating Receptor α（PPARα） and the Target Gene in the Liver of Hyperlipemia Rat

Ye Yong~1; Wang Jianing~2; Wang Daowen~2; et al.

doi:10.13288/j.11-2166/r.2006.01.036

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Effects of Huatan Huoxue Prescription on Expressions of Peroxisome Proliferation Substance Activating Receptor α（PPARα） and the Target Gene in the Liver of Hyperlipemia Rat

更新时间：2021-11-21

- Effects of Huatan Huoxue Prescription on Expressions of Peroxisome Proliferation Substance Activating Receptor α（PPARα） and the Target Gene in the Liver of Hyperlipemia Rat
- Journal of Traditional Chinese Medicine Issue 1, Pages: 53-55(2006)
- 作者机构：
  
  1. 江汉大学医学与生命科学学院中医系
  2. 华中科技大学同济医学院附属同济医院
  3. 湖北中医学院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2006.01.036
  CLC： R285
- Published：2006
- 稿件说明：
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[1]叶勇,王家宁,汪道文,梅国强,刘松林.化痰活血方对高脂血症大鼠肝脏过氧化物酶体增殖物激活受体α及其目标基因表达的影响[J].中医杂志,2006(01):53-55.

Ye Yong~1, Wang Jianing~2, Wang Daowen~2, et al. Effects of Huatan Huoxue Prescription on Expressions of Peroxisome Proliferation Substance Activating Receptor α（PPARα） and the Target Gene in the Liver of Hyperlipemia Rat[J]. Journal of Traditional Chinese Medicine2006, (1): 53-55.
[1]叶勇,王家宁,汪道文,梅国强,刘松林.化痰活血方对高脂血症大鼠肝脏过氧化物酶体增殖物激活受体α及其目标基因表达的影响[J].中医杂志,2006(01):53-55. DOI： 10.13288/j.11-2166/r.2006.01.036.

Ye Yong~1, Wang Jianing~2, Wang Daowen~2, et al. Effects of Huatan Huoxue Prescription on Expressions of Peroxisome Proliferation Substance Activating Receptor α（PPARα） and the Target Gene in the Liver of Hyperlipemia Rat[J]. Journal of Traditional Chinese Medicine2006, (1): 53-55. DOI： 10.13288/j.11-2166/r.2006.01.036.

摘要

目的:观察化痰活血方对高脂血症大鼠肝脏过氧化物酶体增殖物激活受体α（PPARα）、乙酰辅酶A氧化酶（ACO）表达的影响。方法:建立高脂血症大鼠模型后分别给予化痰活血方大、中、小剂量及力平脂治疗

检测其相关指标。结果:化痰活血方能显著降低高脂血症大鼠血清总胆固醇（TC）、甘油三酯（TG）的水平

增强肝脏PPARα、ACO mRNA的表达。结论:化痰活血方增强PPARα、ACO mRNA的表达可能是其治疗高脂血症的分子机制之一。

Abstract

Objective:To observe effects of Huatan Huoxue Prescription on expressions of peroxisome proliferation substance activating receptor α （PPAR α） and the target gene acetyl-CoA oxidase（ACO） in the liver of the rat with hyperlipemia.Methods:The rats of hyperlipemia were treated respectively with Huatan Huoxue Prescription of large

middle

small dosages and Lipanthyl

and related indexes were detected.Results:The Huatan Huoxue Prescription could significantly decrease level of serum total cholesterol（TC） and triglyceride（TG）

and strengthened expressions of PPARα and ACO mRNA in the liver of hyperlipemia rats.Conclusion:Increase of expressions of PPARα and ACO mRNA is possibly one of the mechanisms of Huatan Huoxue Prescription in treatment of hyperlipemia.

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