Effects of Yiqi Yangyin Jiedu Fang on Serum Vascular Endothelial Growth Factor and Immunologic Function in the Patient of Lung Cancer

Liu Jiaxiang~1; Niu Hongmei~2

doi:10.13288/j.11-2166/r.2006.03.021

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Effects of Yiqi Yangyin Jiedu Fang on Serum Vascular Endothelial Growth Factor and Immunologic Function in the Patient of Lung Cancer

更新时间：2021-11-21

- Effects of Yiqi Yangyin Jiedu Fang on Serum Vascular Endothelial Growth Factor and Immunologic Function in the Patient of Lung Cancer
- Journal of Traditional Chinese Medicine Issue 3, Pages: 190-192(2006)
- 作者机构：
  
  1. 上海中医药大学附属龙华医院肿瘤科
  2. 上海中医药大学2002级
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2006.03.021
  CLC： R273
- Published：2006
- 稿件说明：
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[1]刘嘉湘,牛红梅.益气养阴解毒方对肺癌患者血清血管内皮生长因子及免疫功能的影响[J].中医杂志,2006(03):190-192.

Liu Jiaxiang~1, Niu Hongmei~2. Effects of Yiqi Yangyin Jiedu Fang on Serum Vascular Endothelial Growth Factor and Immunologic Function in the Patient of Lung Cancer[J]. Journal of Traditional Chinese Medicine2006, (3): 190-192.
[1]刘嘉湘,牛红梅.益气养阴解毒方对肺癌患者血清血管内皮生长因子及免疫功能的影响[J].中医杂志,2006(03):190-192. DOI： 10.13288/j.11-2166/r.2006.03.021.

Liu Jiaxiang~1, Niu Hongmei~2. Effects of Yiqi Yangyin Jiedu Fang on Serum Vascular Endothelial Growth Factor and Immunologic Function in the Patient of Lung Cancer[J]. Journal of Traditional Chinese Medicine2006, (3): 190-192. DOI： 10.13288/j.11-2166/r.2006.03.021.

摘要

目的:观察益气养阴解毒方对非小细胞肺癌（NSCLC）患者血清血管内皮生长因子（VEGF）及免疫功能的影响。方法:51例NSCLC患者

随机分为中药组、化疗组和化疗+中药组

观察各组疗效以及临床证候、体力状况、免疫指标、血清VEGF变化情况。结果:中药组和化疗+中药组治疗后肿瘤稳定率均高于化疗组

但差异无显著性

临床症状、体力状况改善均明显优于化疗组（均P<0.05）。中药+化疗组能明显提高白细胞介素2水平

下调可溶性白细胞介素2受体（sIL-2）水平（均P<0.01）

且疗效明显优于化疗组（P<0.05）;中药组能显著提高T细胞总数

下调sIL-2水平（P<0.05或P<0.01）。中药+化疗组治疗后血清VEGF水平明显下降（P<0.01）。结论:益气养阴解毒方治疗NSCLC

有缩小稳定瘤灶

提高免疫功能和生存质量

降低血清VEGF水平的作用。

Abstract

Objective:To observe effects of Yiqi Yangyin Jiedu Fang on serum vascular endothelial growth factor（VEGF） and Immunologic function in the patient of non-small cell lung cancer（NSCLC）.Methods:Fifty-one cases of NSCLC were randomly divided into a Chinese medicine group

a chemotherapy group and a chemotherapy plus Chinese medicine group.The therapeutic effect and changes of clinical symptoms

physical strength

immunologic indexes and serum VEGF before and after treatment were investigated in all groups.Results:Tumor stable rate in Chinese medicine group and chemotherapy plus Chinese medicine group after treatment was higher than that in chemotherapy group with no significant difference

but improvement of clinical symptoms and physical strength in Chinese medicine group and chemotherapy plus Chinese medicine group after treatment was significantly superior to that in chemotherapy group（both P<0.05）.Interleukin-2（IL-2） level was significantly increased

and soluble IL-2 receptor（sIL-2R） were down-regulated（both P<0.01） in Chinese medicine plus chemotherapy group

and the therapeutic effect was significantly higher than that of the chemotherapy group（P<0.05）; The total T-cell count was significantly increased and the sIL-2 level was down-regulated in Chinese medicine group（P<0.05 or P<0.01）.Serum VEGF level significantly decreased after treatment in the Chinese medicine plus chemotherapy group（P<0.01）.Conclusion:Yiqi Yangyin Jiedu Fang has functions of reducing and stabilizing the tumor focus

increasing immunologic function and quality of life

and decreasing VEGF level for the patient of NSCLC.

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