Objective:To probe the interfering action of Xiayuxue Decoction on hepatic fibrosis at progressive stage in rats .Methods:The rats were given subcutaneous injection of 2 ml of 50% carbon tetrachloride（CCl

4

）

twice each week. At the 9th week they were randomly assigned to a model control group

a Xiayuxue Decoction group and a Xiaochaihu Decoction group（administration by intragastrical perfusion）.At the same time

CCl

4

was continuously given till the end of the 12th week

and the rats were killed for taking samples.Changes of hepatic functions

hepatic histopathology

and hydroxyproline（Hyp） content in the liver were investigated.Results:At the end of 8th week

model rats showed abnormal hepatic function

Hyp content of the hepatic tissue increased significantly with obvious hepatic fibrosis; at the end of 12th week

aspartic aminotransferase（AST）

alkaline phosphatase（ALP）

r-L-glutamyl transpeptidase（GGT）

total bilirubin（TBil）

and Hyp increased further in the model control group

ALP

GGT

TBil being significantly higher than those at the 8th week（P

<

0.05）.Compared with the model control group at the 12th week

alanine aminotransferase（ALT）

AST

ALP

GGT

TBil

Hyp decreased significantly（P

<

0.05 or P

<

0.01）.Conclusion:Xiayuxue Decoction can significantly inhibit the development of hepatic fibrosis at the progressive stage under the continuous stimulation of the modeling factors

and its therapeutic effect is superior to that of Xiaochaihu Decoction.The correlativity of prescription with syndrome has pathological basis.