Effects of Ruangan Yin on Cytokines and Ultrastructure of Hepatocytes in Immunol Hepatic Fibrosis Rats

Zhang Guoliang~1; Dai Min~2; Xu Fan~2; et al.

doi:10.13288/j.11-2166/r.2006.03.036

您当前的位置：

首页 >

文章列表页 >

Effects of Ruangan Yin on Cytokines and Ultrastructure of Hepatocytes in Immunol Hepatic Fibrosis Rats

更新时间：2021-11-21

- Effects of Ruangan Yin on Cytokines and Ultrastructure of Hepatocytes in Immunol Hepatic Fibrosis Rats
- Journal of Traditional Chinese Medicine Issue 3, Pages: 219-221(2006)
- 作者机构：
  
  1. 安徽中医学院第一附属医院感染科
  2. 安徽中医学院
  3. 安徽省立医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2006.03.036
  CLC： R285
- Published：2006
- 稿件说明：
移动端阅览
[1]张国梁,戴敏,许钒,汪电雷,方朝晖,查安生,胡闻.软肝饮对免疫性肝纤维化大鼠细胞因子及肝细胞超微结构的影响[J].中医杂志,2006(03):219-221.

Zhang Guoliang~1, Dai Min~2, Xu Fan~2, et al. Effects of Ruangan Yin on Cytokines and Ultrastructure of Hepatocytes in Immunol Hepatic Fibrosis Rats[J]. Journal of Traditional Chinese Medicine2006, (3): 219-221.
[1]张国梁,戴敏,许钒,汪电雷,方朝晖,查安生,胡闻.软肝饮对免疫性肝纤维化大鼠细胞因子及肝细胞超微结构的影响[J].中医杂志,2006(03):219-221. DOI： 10.13288/j.11-2166/r.2006.03.036.

Zhang Guoliang~1, Dai Min~2, Xu Fan~2, et al. Effects of Ruangan Yin on Cytokines and Ultrastructure of Hepatocytes in Immunol Hepatic Fibrosis Rats[J]. Journal of Traditional Chinese Medicine2006, (3): 219-221. DOI： 10.13288/j.11-2166/r.2006.03.036.

摘要

目的:观察中药复方软肝饮对免疫性肝纤维化模型大鼠细胞因子及肝细胞超微结构的影响。方法:对人血白蛋白（HSA）诱导的免疫性肝纤维化大鼠模型予软肝饮小剂量（1g/kg）、大剂量（2g/kg）灌胃给药

连续8周

以鳖甲软肝片和秋水仙碱为阳性对照药;测定模型大鼠肿瘤坏死因子α（TNF-α）、白细胞介素1（IL-1）、转化生长因子β1（TGF-β1）含量的变化;用电镜观察肝细胞超微结构的变化。结果:软肝饮显著降低模型大鼠血清TNF-α、IL-1、TGF-β1含量

并可保护模型大鼠肝细胞超微结构。结论:软肝饮可能通过恢复肝细胞形态及降低炎症细胞因子含量而起到抗肝纤维化的作用。

Abstract

Objective:To observe effects of Ruan Gan Yin on cytokines and ultrastructure of hepatocytes in the rat of immunol hepatic fibrosis.Methods:Immunol hepatic fibrosis model rats induced by human serum albumin were given small dose（1g/kg）

large dose（2g/kg） of Ruangan Yin by intragastrical perfusion for 8 consecutive weeks

with Biejia Ruangan Tablets and colchiichine used as positive control medicine. Changes of tumor necrosis factor-α（TNF-α）

interleukin-1（IL-1）

transforming growth factor β

（TGF-β

） contents and ultrastructure were investigated in the model rats.Results:Ruangan Yin could significantly decrease serum TNF-α

IL-1 and TGF-β

contents and protect ultrastructure of hepatocytes in model rats.Conclusion:Ruangan Yin exerts functions of anti-hepatic fibrosis possibly through restoring appearance of cell organs with secreting functions and decreasing contents of inflammatory cytokines.

关键词

Keywords

references

查看原文

Views

177

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Study on TCM Recipe and Syndrome of Dimethylnitrosamine-induced Hepatic Fibrosis in Rats

Effect of Xiaoqinglong Decoction （小青龙汤） on Th2 Immune Responses and Nasal Mucosal TSLP/OX40L Pathway in Allergic Rhinitis Model Rats

A Preliminary Discussion on the Method of Regulating Qi and Calming the Mind

Exploration on the Connotation and Application of the Three Aspects of "Dietary Inquiry" for "Appetite" "Eating Capacity" "Food Preference"

Current Status and Strategic Recommendations for Randomized Controlled Trials on Functional Dyspepsia-Irritable Bowel Syndrome Comorbidity：from a Real-World Research Perspective

Related Author

Wang Lei

Liu Ping

Mu Yongping

et al.

龙爱华

顾宏图

陈高峰

Related Institution

Institute of Hepatic Disease,Shanghai University of TCM

上海中医药大学附属曙光医院

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰