Clinical Study on Treatment of 40 Cases of Gastric Cancer with Jiawei Sijun Granules Combined with Chemotherapy

Hu Shaoming; Tu Shenghao; Dong Hui; et al.

doi:10.13288/j.11-2166/r.2006.04.020

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Clinical Study on Treatment of 40 Cases of Gastric Cancer with Jiawei Sijun Granules Combined with Chemotherapy

更新时间：2021-11-21

- Clinical Study on Treatment of 40 Cases of Gastric Cancer with Jiawei Sijun Granules Combined with Chemotherapy
- Journal of Traditional Chinese Medicine Issue 4, Pages: 274-276(2006)
- 作者机构：
  
  1. 华中科技大学同济医学院附属同济医院中西医结合研究所、肿瘤科
  2. 华中科技大学同济医学院附属同济医院中西医结合研究所、肿瘤科湖北省武汉市解放大道1095号,430030
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2006.04.020
  CLC： R735.2
- Published：2006
- 稿件说明：
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[1]胡少明,涂胜豪,董慧,王开富,何邦顺,杨金香.加味四君颗粒联合化疗治疗胃癌40例临床研究[J].中医杂志,2006(04):274-276.

Hu Shaoming, Tu Shenghao, Dong Hui, et al. Clinical Study on Treatment of 40 Cases of Gastric Cancer with Jiawei Sijun Granules Combined with Chemotherapy[J]. Journal of Traditional Chinese Medicine2006, (4): 274-276.
[1]胡少明,涂胜豪,董慧,王开富,何邦顺,杨金香.加味四君颗粒联合化疗治疗胃癌40例临床研究[J].中医杂志,2006(04):274-276. DOI： 10.13288/j.11-2166/r.2006.04.020.

Hu Shaoming, Tu Shenghao, Dong Hui, et al. Clinical Study on Treatment of 40 Cases of Gastric Cancer with Jiawei Sijun Granules Combined with Chemotherapy[J]. Journal of Traditional Chinese Medicine2006, (4): 274-276. DOI： 10.13288/j.11-2166/r.2006.04.020.

摘要

目的:观察加味四君颗粒、贞芪扶正颗粒联合化疗治疗胃癌的临床疗效。方法:120例胃癌术后患者按数字化随机法分为加味四君组（加味四君颗粒加化疗）、贞芪扶正组（贞芪扶正颗粒加化疗）、对照组（单纯化疗）

每组40例。观察治疗前后卡氏评分、外周血象和血液动力学变化

并观察自然杀伤（NK）细胞、T淋巴细胞亚群、可溶性白介素2受体（sIL-2R）等指标的变化。结果:加味四君组和贞芪扶正组胃癌患者化疗后生存质量明显改善

外周血白细胞和红细胞数稳定

单纯化疗组外周血白细胞、红细胞、血红蛋白浓度均较化疗前明显下降;加味四君组和贞芪扶正组患者化疗后NK细胞活性、CD3、CD4T细胞数和CD4/CD8比值升高

血清sIL-2R的浓度明显下降;单纯化疗组化疗后患者NK细胞活性、CD4T细胞数和CD4/CD8比值下降

血清sIL-2R的浓度升高而全血黏度无明显改变。结论:加味四君颗粒、贞芪扶正颗粒对化疗有增效减毒作用

联合化疗对胃癌术后患者机体免疫功能有保护和促进作用

并能防治化疗引起的骨髓抑制。

Abstract

Objective:To observe clinical therapeutic effects of Jiawei Sijun Granules and Zhenqi Fuzheng Granules combined with chemotherapy on gastric cancer.Methods:One hundred and twenty cases of gastric cancer after operation were randomly divided into 3 groups

a Jiawei Sijun group（Jiawei Sijun Granules combined with chemotherapy）

a Zhenqi Fuzheng group（Zhengqi Fuzheng Granules combined with chemotherapy） and a control group（simple chemotherapy）

40 cases in each group.Changes of Karnofsky score

peripheral blood and hemorrheologic indexes

NK cell activity

T-lymphocyte subgroup and serum soluble interleukin-2 receptor（sIL-2R） before and after treatment were determined.Results:After chemotherapy

quality of life improved

and peripheral blood leukocyte and erythrocyte counts in both Jiawei Sijun group and Zhenqi Fuzheng group were stable.Peripheral blood leukocyte

erythrocyte and hemoglobin content in the control group decreased significantly.NK cell activity

and CD

T-lymphocytes and the ratio of CD

/CD

increased significantly

and serum sIL-2R content decreased significantly in Jiawei Sijun group and Zhenqi Fuzheng group.NK cell activity

T-lymphocyte count and the ratio of CD

/CD

increased significantly and serum sIL-2R level increased in the control group.Conclusion:Jiawei Sijun Granules and Zhenqi Fuzheng Granules can increase the therapeutic effect and reduce side effects caused by chemotherapy

and their combination with chemotherapy can protect immune functions of gastric cancer patient after operation and prevent bone marrow suppression induced by chemotherapy.

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