Effects of Xuanfa Moyuan Prescription on Ultrastructure of Articular Synovial Cells in Collagen Immune Arthritis Rats

Jia Hongwei; Zhao Ning; Li Yan; et al.

doi:10.13288/j.11-2166/r.2006.04.036

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Effects of Xuanfa Moyuan Prescription on Ultrastructure of Articular Synovial Cells in Collagen Immune Arthritis Rats

更新时间：2021-11-21

- Effects of Xuanfa Moyuan Prescription on Ultrastructure of Articular Synovial Cells in Collagen Immune Arthritis Rats
- Journal of Traditional Chinese Medicine Issue 4, Pages: 301-302(2006)
- 作者机构：
  
  1. 中国中医科学院基础理论研究所
  2. 北京中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2006.04.036
  CLC： R285
- Published：2006
- 稿件说明：
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[1]贾红伟,赵宁,李艳,张皖东,吕诚,赵宏艳,铃木聪,王少君,滕静如,吕爱平.宣发膜原方对胶原免疫性关节炎大鼠关节滑膜细胞超微结构的影响[J].中医杂志,2006(04):301-302.

Jia Hongwei, Zhao Ning, Li Yan, et al. Effects of Xuanfa Moyuan Prescription on Ultrastructure of Articular Synovial Cells in Collagen Immune Arthritis Rats[J]. Journal of Traditional Chinese Medicine2006, (4): 301-302.
[1]贾红伟,赵宁,李艳,张皖东,吕诚,赵宏艳,铃木聪,王少君,滕静如,吕爱平.宣发膜原方对胶原免疫性关节炎大鼠关节滑膜细胞超微结构的影响[J].中医杂志,2006(04):301-302. DOI： 10.13288/j.11-2166/r.2006.04.036.

Jia Hongwei, Zhao Ning, Li Yan, et al. Effects of Xuanfa Moyuan Prescription on Ultrastructure of Articular Synovial Cells in Collagen Immune Arthritis Rats[J]. Journal of Traditional Chinese Medicine2006, (4): 301-302. DOI： 10.13288/j.11-2166/r.2006.04.036.

摘要

目的:探讨宣发膜原方对胶原免疫性关节炎（CIA）的治疗机理

为研究类风湿性关节炎（RA）的发病和损伤机理提供实验依据。方法:以CIA作为RA的动物模型

以达原饮加减方作为宣发膜原法代表方

检测CIA大鼠踝关节病理改变及膝关节滑膜组织超微结构的变化。结果:宣发膜原方可以有效地减轻CIA大鼠病理损伤

提高滑膜细胞中B型滑膜细胞的比例

减少滑膜细胞中的高尔基体、粗面内质网等细胞器。结论:宣发膜原方能够减轻CIA病理损伤

改善滑膜细胞超微结构。

Abstract

Objective:To explore mechanisms of Xuanfa Moyuan Prescription in treatment of collagen immune arthritis（CIA）

so as to provide experimental basis of pathogenesis and injury mechanism of rheumatoid arthritis（RA）.Methods:Using CIA as RA animal model and modified Dayuan Yin as a representative prescription of the Xuanfa Moyuan Method

pathological changes of the ankle joint and the ultrastructure of synovial tissue of the knee joint in CIA rats were investigated.Results:Xuanfa Moyuan Prescription could effectively alleviate pathological injury

increase the ratio of B type synovial cell in the synovial cells in CIA rats

and reduce Golgi body

rough surface endoplasmic reticulum and other cell organs in the synovial cells.Conclusion:Xuanfa Moyuan Prescription can alleviate pathological injury of CIA and improve ultrastructure of the synovial cell.

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