Clinical Study on Wendan Decoction Combined with Clozapine for Treatment of 30 Cases of Schizophrenia

Tan Bin

doi:10.13288/j.11-2166/r.2006.05.023

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Clinical Study on Wendan Decoction Combined with Clozapine for Treatment of 30 Cases of Schizophrenia

更新时间：2021-11-20

- Clinical Study on Wendan Decoction Combined with Clozapine for Treatment of 30 Cases of Schizophrenia
- Journal of Traditional Chinese Medicine Issue 5, Pages: 361-362(2006)
- 作者机构：
  
  湖北民族学院医学院神经精神病学教研室湖北省恩施市学院路39号,445000
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2006.05.023
  CLC： R749.3
- Published：2006
- 稿件说明：
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[1]谭斌.温胆汤联合氯氮平治疗精神分裂症30例临床研究[J].中医杂志,2006(05):361-362.

Tan Bin. Clinical Study on Wendan Decoction Combined with Clozapine for Treatment of 30 Cases of Schizophrenia[J]. Journal of Traditional Chinese Medicine2006, (5): 361-362.
[1]谭斌.温胆汤联合氯氮平治疗精神分裂症30例临床研究[J].中医杂志,2006(05):361-362. DOI： 10.13288/j.11-2166/r.2006.05.023.

Tan Bin. Clinical Study on Wendan Decoction Combined with Clozapine for Treatment of 30 Cases of Schizophrenia[J]. Journal of Traditional Chinese Medicine2006, (5): 361-362. DOI： 10.13288/j.11-2166/r.2006.05.023.

摘要

目的:探讨温胆汤治疗或协同治疗精神分裂症的疗效及副反应。方法:以实验组给予温胆汤

实验组给予温胆汤加氯氮平

对照组给予氯氮平治疗精神分裂症各30例作对照研究

采用阳性与阴性症状量表（PANSS）、不良反应症状量表（TESS）评定疗效及副反应。结果:实验组显效率70%

有效率30%;实验组显效率36.6%

有效率50%;对照组显效率43.6%

有效率56.4%;两实验组的药物副反应明显少于对照组。结论:温胆汤治疗精神分裂症疗效确切

在协同治疗时疗效更佳

且安全性较高

对症状的改善更好

并可明显减少抗精神药物的用量及EPS发生率。

Abstract

Objective:To probe the therapeutic effect and adverse reaction of Wendan Decoction in combination with Clozapine for treatment of schizophrenia.Methods:Three groups were set up in the study

30 cases in each.The group Ⅰ were treated with Wendan Decoction

group Ⅱ with Wendan decoction plus Clozapine

and the control group with Clozapine.Positive and negative symptom scale（PANSS）and treatment emergent symptom scale（TESS）were used for evaluation of the therapeutic effect and adverse reaction.Results:The markedly effective rate was 70% and the effective rate was 30% in group Ⅱ

36.6% and 50% in the group Ⅰ

and 43.6% and 56.4% in the control group respectively.The adverse reactions in group Ⅰ and group Ⅱ were less than those in the control group.Conclusion:Wendan Decoction has a definite therapeutic effect on schizophrenia and the combined treatment has better therapeutic effect with high safety.It can improve symptoms and reduce the dosage of antipsychotics and the incidence of EPS.

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