Objective:To probe the mechanism of Dachengqi Decoction combined with the treatment principle of promoting production of body fluid with sweet-flavored and cold-natured drugs on the earth-dry and water-exhaust syndrome.Methods:Chinchilla Giganta rabbits were randomly divided into four groups

i.e. blank control group

pathological model group

timely purgation to preserve Yin treatment group and treatment group of purgation with drugs sweet in favor and cold in nature.Changes of symptoms

signs

pathological changes of organs

WBC count

nitric oxide（NO）

superoxide dismutase（SOD）

malondialdehyde（MDA）

middle molecular substances（MMS）

sulfydryl（-SH）

K+ and Na+

and viscosities of whole blood and plasma before and after treatment were investigated.Results:There were significant differences in decrease of body temperature

increases of SOD

MMS

K+ and Na+

decreases of NO

MDA

-SH and viscosities of whole blood and plasma as the two treatment groups compared with the pathological model group（P<0.05 or P<0.01）.There was also significant difference between the two treatment groups（P<0.05）.Conclusion:Both the timely purgation to preserve Yin method and the method for purgation with sweet-favored and cold-natured drugs have good corrective and therapeutic effect on the animal with the earth-dry and water-exhaust syndrome

the effect of the latter being superior to that of the former.