Study on Shenghe Powder for Reversion of Multidrug Resistance of SGC7901/VCR Cells of Gastric Cancer

Xia Yuesheng1; Wang Jianhua1; Wu Yongzhong2; et al.

doi:10.13288/j.11-2166/r.2006.06.041

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Study on Shenghe Powder for Reversion of Multidrug Resistance of SGC7901/VCR Cells of Gastric Cancer

更新时间：2021-11-17

- Study on Shenghe Powder for Reversion of Multidrug Resistance of SGC7901/VCR Cells of Gastric Cancer
- Journal of Traditional Chinese Medicine Issue 6, Pages: 459-460(2006)
- 作者机构：
  
  1. 中国人民解放军总后勤部第五职工医院
  2. 中国人民解放军第四军医大学唐都医院
  3. 山西中医学院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2006.06.041
  CLC： R273
- Published：2006
- 稿件说明：
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[1]夏跃胜,王建华,吴永忠,王欢.圣和散逆转胃癌SGC7901/VCR细胞多药耐药的研究[J].中医杂志,2006(06):459-460.

Xia Yuesheng1, Wang Jianhua1, Wu Yongzhong2, et al. Study on Shenghe Powder for Reversion of Multidrug Resistance of SGC7901/VCR Cells of Gastric Cancer[J]. Journal of Traditional Chinese Medicine2006, (6): 459-460.
[1]夏跃胜,王建华,吴永忠,王欢.圣和散逆转胃癌SGC7901/VCR细胞多药耐药的研究[J].中医杂志,2006(06):459-460. DOI： 10.13288/j.11-2166/r.2006.06.041.

Xia Yuesheng1, Wang Jianhua1, Wu Yongzhong2, et al. Study on Shenghe Powder for Reversion of Multidrug Resistance of SGC7901/VCR Cells of Gastric Cancer[J]. Journal of Traditional Chinese Medicine2006, (6): 459-460. DOI： 10.13288/j.11-2166/r.2006.06.041.

摘要

目的探讨中药圣和散逆转胃癌耐药细胞SGC7901/VCR多药耐药的机制。方法圣和散（浓度2.5、5和10mg/ml）处理胃癌耐药细胞SGC7901/VCR

用流式细胞技术检测P-糖蛋白（P-gp）表达

免疫组织化学SABC法及图像分析技术检测B细胞淋巴瘤/白血病基因-2（Bcl-2）。结果实验组SGC7901/VCR细胞Bcl-2表达A值（121.34±0.16）明显高于对照组（104.37±0.089）（P<0.05）

Bcl-2表达减少

P-gp表达也明显降低。结论圣和散能逆转胃癌耐药细胞SGC7901/VCR多药耐药

其作用可能与调节Bcl-2和P-gp表达有关。

Abstract

Objective:To explore the mechanism of Shenghe Powder（SHP） in reversion of multidrug resistence of SGC7901/VCR cells of gastric cancer.Methods:Gastric cancer drug-resistance cells SGC7901/VCR were treated with SHP at concentrations of 2.5

5.0 and 10mg/ml.The expression of P-glycoprotein（P-gp） was detected with flowcytometry and B-cell lymphoma/leukemia-2（Bcl-2） protein was examined by immunohistochemical SABC method and imaging analysis.Results:In SHP treated group

A value of Bcl-2 in SGC7901/VCR cells was significantly higher than that in the control group（P<0.05）

and the expression of Bcl-2 and P-gp was significantly down-regulated.Conclusion:SHP can reverse the multidrug resistance of SGC7901/VCR

which is possibly related with the changes of the expressions of Bcl-2 and P-gp.

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