Effects of Acupuncture on Nitric Oxide and Nitric Oxide Synthetase in Multi-Infarctional Dementia Rats

Liu Cunzhi~1; Yu Jianchun~1; Wang Tong~2; et al.

doi:10.13288/j.11-2166/r.2006.07.017

您当前的位置：

首页 >

文章列表页 >

Effects of Acupuncture on Nitric Oxide and Nitric Oxide Synthetase in Multi-Infarctional Dementia Rats

更新时间：2021-11-17

- Effects of Acupuncture on Nitric Oxide and Nitric Oxide Synthetase in Multi-Infarctional Dementia Rats
- Journal of Traditional Chinese Medicine Issue 7, Pages: 502-504(2006)
- 作者机构：
  
  1. 天津中医药大学第一附属医院老年病研究室
  2. 天津中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2006.07.017
  CLC： R245
- Published：2006
- 稿件说明：
移动端阅览
[1]刘存志,于建春,王彤,韩景献.针刺对多发梗死性痴呆大鼠一氧化氮/一氧化氮合酶的影响[J].中医杂志,2006(07):502-504.

Liu Cunzhi~1, Yu Jianchun~1, Wang Tong~2, et al. Effects of Acupuncture on Nitric Oxide and Nitric Oxide Synthetase in Multi-Infarctional Dementia Rats[J]. Journal of Traditional Chinese Medicine2006, (7): 502-504.
[1]刘存志,于建春,王彤,韩景献.针刺对多发梗死性痴呆大鼠一氧化氮/一氧化氮合酶的影响[J].中医杂志,2006(07):502-504. DOI： 10.13288/j.11-2166/r.2006.07.017.

Liu Cunzhi~1, Yu Jianchun~1, Wang Tong~2, et al. Effects of Acupuncture on Nitric Oxide and Nitric Oxide Synthetase in Multi-Infarctional Dementia Rats[J]. Journal of Traditional Chinese Medicine2006, (7): 502-504. DOI： 10.13288/j.11-2166/r.2006.07.017.

摘要

目的:探讨针刺对多发梗死性痴呆（MID）大鼠一氧化氮（NO）/一氧化氮合酶（NOS）的影响。方法:MID大鼠随机分为模型组、针刺组和非穴组

并设正常组和假手术组。观察各组大鼠血清及不同脑区NO含量、NOS活性及各脑区神经元型NOS（nNOS）基因的表达。结果:与正常组比较

模型组大鼠血清、皮质、海马NO含量升高

海马及纹状体NOS活性升高

各脑区nNOS mRNA及蛋白表达增强。针刺可明显逆转上述异常改变。结论:针刺可抑制MID大鼠nNOS的过度表达

降低NOS活性

减少NO的产生

从而通过NO/NOS途径起到一定的神经保护作用。

Abstract

Objective:To probe into effects of acupuncture on nitric oxide （NO） and nitric oxide synthetase（NOS） in multi-infarctional dementia（MID） rats.Methods:MID rats were randomly divided into model group

acupuncture group

non-acupoint group

normal group and sham-operation group.NO contents and NOS activities in serum and different brain regions

and nNOS gene expression in different brain regions were investigated.Results:NO contents in serum

cortex and hippocampus

NOS activities in hippocampus and striatum

and expressions of nNOS mRNA and protein in different regions increased in model group as compared with those of normal group.Acupuncture could significantly reverse the above abnormal changes.Conclusion:Acupuncture can inhibit over-expression of nNOS

decrease activity of NOS and reduce NO generation in MID rats

so as to exert a certain nerve protective action via NO/NOS pathway.

关键词

Keywords

references

查看原文

Views

209

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Exploring the Comorbidity Mechanism，Prevention and Treatment Strategies of Rheumatoid Arthritis with Coronary Atherosclerotic Heart Disease Based on Collateral Disease Theory

LI Guolie's Experience in Treating Orthostatic Hypotension from the Perspective of "Raising the Clear and Directing the Turbid Downward"

Exploration on the Connotation and Application of the Three Aspects of "Dietary Inquiry" for "Appetite" "Eating Capacity" "Food Preference"

Research on the Correlation Between "Tiangui （天癸）" and Female Reproductive Genetic Diseases

Current Status and Strategic Recommendations for Randomized Controlled Trials on Functional Dyspepsia-Irritable Bowel Syndrome Comorbidity：from a Real-World Research Perspective

Related Author

No data

Related Institution

No data

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰